TABLE 4.

Logistic Regression of Key Patient Characteristics on Axitinib Dose Modifications

Variable	Odds Ratio	95% CI
Dose decrease
Age	1.015	0.998-1.033
Gender (female vs. male)	0.695	0.462-1.047
Baseline hypothyroidism treatment (yes vs. no)	1.662	1.088-2.539
Other baseline treatment (yes vs. no)	0.913	0.639-1.306
Dose increase only
Age	0.958	0.941-0.975
Gender (female vs. male)	0.573	0.364-0.903
Baseline hypothyroidism treatment (yes vs. no)	2.149	1.353-3.413
Other baseline treatment (yes vs. no)	0.468	0.314-0.697
Dose increase then decrease
Age	0.989	0.967-1.012
Gender (female vs. male)	1.033	0.627-1.702
Baseline hypothyroidism treatment (yes vs. no)	2.381	1.396-4.060
Other baseline treatment (yes vs. no)	0.762	0.469-1.237
CI = confidence interval.