TABLE 1.
Demographic and Clinical Characteristics
| Characteristic | Sunitinib n = 609 | Pazopanib n = 183 | P Value |
|---|---|---|---|
| Age, mean [SD] | 62.61 [10.38] | 61.93 [11.27] | 0.443 |
| Age group, n (%) | |||
| 18-34 | 2 (0.33) | 2 (1.09) | 0.252 |
| 35-44 | 22 (3.61) | 6 (3.28) | |
| 45-54 | 93 (15.27) | 38 (20.77) | |
| 55-64 | 265 (43.51) | 69 (37.70) | |
| 65+ | 227 (37.27) | 68 (37.16) | |
| Gender, n (%) | |||
| Male | 443 (72.74) | 138 (75.41) | 0.474 |
| Female | 166 (27.26) | 45 (24.59) | |
| Geographic region, n (%) | |||
| Northeast | 87 (14.29) | 22 (12.02) | 0.832 |
| North Central | 162 (26.60) | 52 (28.42) | |
| South | 220 (36.12) | 68 (37.16) | |
| West | 132 (21.67) | 40 (21.86) | |
| Unknown | 8 (1.31) | 1 (0.55) | |
| Continuous enrollment days (pre-index), mean [SD] | 856.67 [399.48] | 962.21 [436.43] | 0.002a |
| CCI score, mean [SD] | 7.98 [2.90) | 8.11 [2.80] | 0.604 |
| Metastatic diagnoses during 6 months pre-index, n (%) | 495 (81.28) | 151 (82.51) | 0.706 |
| Metastatic diagnosis from January 1, 2008 through September 30, 2013 | 578 (94.91) | 179 (97.81) | 0.094 |
| Days from earliest pre-index RCC diagnosis, January 1, 2008, to index date, mean [SD] | 372.57 [397.26] | 490.75 [435.17] | < 0.001a |
| Number of all-cause inpatient admissions, during 6 months pre-index, n (%) | 322 (52.87) | 90 (49.18) | 0.381 |
| Per patient mean [SD] | 0.72 [0.82] | 0.86 [1.23] | 0.145 |
| Inpatient admissions with any RCC diagnosis, during 6 months pre-index, n (%) | 264 (43.35) | 73 (39.89) | 0.407 |
| Per patient mean [SD] | 0.55 [0.73] | 0.64 [1.04] | 0.228 |
aP < 0.05.
CCI = Charlson Comorbidity Index; RCC = renal cell carcinoma; SD = standard deviation.