TABLE 3.

Mutation Incidence for Imatinib

Mutation	Criteria Defining Treatment Failure
	Composite			MCyR			CCyR			Other
	Number of Patients Exposed to Treatment	Composite Mutations	Incidence (%)	Number of Patients Exposed to Treatment	Number of Mutations	Incidence (%)	Number of Patients Exposed to Treatment	Number of Mutations	Incidence (%)	Number of Patients Exposed to Treatment	Number of Mutations	Incidence (%)
M244V	1,277	7	0.55	947	2	0.21	947	0	0	1,277	5	0.39
L248V	1,277	1	0.08	947	0	0	947	0	0	1,277	1	0.08
G250E	1,277	9	0.63	947	1	0.11	947	2	0.21	1,277	6	0.47
Q252H	1,277	7	0.55	947	0	0	947	0	0	1,277	7	0.55
Y253F	1,277	6	0.47	947	1	0.11	947	0	0	1,277	5	0.39
Y253H	1,277	6	0.47	947	1	0.11	947	0	0	1,277	5	0.39
E255K	1,277	16	1.25	947	3	0.32	947	1	0.11	1,277	12	0.94
E255V	1,277	2	0.16	947	1	0.11	947	0	0	1,277	1	0.08
D276G	1,205	2	0.17	947	1	0.11	947	0	0	1,205	1	0.08
V299L	1,277	1	0.08	947	0	0	947	0	0	1,277	1	0.08
T315A	1,205	0	0	947	0	0	947	0	0	1,205	0	0
T315I	1,277	15	1.17	947	6	0.63	947	4	0.42	1,277	5	0.39
F317L	1,277	4	0.31	947	0	0	947	0	0	1,277	4	0.31
F317C	1,205	0	0	947	0	0	947	0	0	1,205	0	0
F317I	1,205	0	0	947	0	0	947	0	0	1,205	0	0
F317V	1,205	0	0	947	0	0	947	0	0	1,205	0	0
M351T	1,277	15	1.17	947	0	0	947	1	0.11	1,277	14	1.10
E355G	1,277	7	0.55	947	1	0.11	947	0	0	1,277	6	0.47
F359C	1,205	1	0.08	947	0	0	947	0	0	1,205	1	0.08
F359V	1,277	11	0.86	947	0	0	947	2	0.21	1,277	9	0.70
F359I	1,205	2	0.17	947	0	0	947	0	0	1,205	2	0.17
H396R	1,134	3	0.26	876	0	0	876	0	0	1,134	3	0.26
E450G	1,134	5	0.44	876	1	0.11	876	1	0.11	1,134	3	0.26
F459K	1,134	6	0.53	876	0	0	876	1	0.11	1,134	5	0.44

CCyR = complete cytogenetic response; MCyR = major cytogenetic response.