Mutation	Criteria Defining Treatment Failure
	Composite			MCyR			CCyR			Other
	Number of Patients Exposed to Treatment	Composite Mutations	Incidence (%)	Number of Patients Exposed to Treatment	Number of Mutations	Incidence (%)	Number of Patients Exposed to Treatment	Number of Mutations	Incidence (%)	Number of Patients Exposed to Treatment	Number of Mutations	Incidence (%)
M244V	360	0	0	102	0	0	102	0	0	360	0	0
L248V	360	0	0	102	0	0	102	0	0	360	0	0
G250E	360	0	0	102	0	0	102	0	0	360	0	0
Q252H	360	0	0	102	0	0	102	0	0	360	0	0
Y253F	360	0	0	102	0	0	102	0	0	360	0	0
Y253H	360	0	0	102	0	0	102	0	0	360	0	0
E255K	360	0	0	102	0	0	102	0	0	360	0	0
E255V	360	0	0	102	0	0	102	0	0	360	0	0
D276G	360	0	0	102	0	0	102	0	0	360	0	0
V299L	360	2	0.56	102	1	0.98	102	1	0.98	360	0	0
T315A	360	0	0	102	0	0	102	0	0	360	0	0
T315I	360	7	1.94	102	0	0	102	0	0	360	7	1.94
F317L	360	2	0.56	102	0	0	102	0	0	360	2	0.56
F317C	360	0	0	102	0	0	102	0	0	360	0	0
F317I	360	1	0.28	102	0	0	102	0	0	360	1	0.28
F317V	360	0	0	102	0	0	102	0	0	360	0	0
M351T	360	0	0	102	0	0	102	0	0	360	0	0
E355G	360	0	0	102	0	0	102	0	0	360	0	0
F359C	360	0	0	102	0	0	102	0	0	360	0	0
F359V	360	0	0	102	0	0	102	0	0	360	0	0
F359I	360	0	0	102	0	0	102	0	0	360	0	0
H396R	360	0	0	102	0	0	102	0	0	360	0	0
E450G	360	0	0	102	0	0	102	0	0	360	0	0
E459K	360	0	0	102	0	0	102	0	0	360	0	0