TABLE 2.
Unadjusted and Adjusted A1c Outcomes 6-12 Months After Index Date
| Overall Cohort | Matched Cohort | |||||||
|---|---|---|---|---|---|---|---|---|
| Overall (N = 3,078) | Clinical Inertia (n = 1,093) | Treatment Intensification (n = 1,985) | P Valuea | Overall (N = 1,760) | Clinical Inertia (n = 880) | Treatment Intensification (n = 880) | P Valuea | |
| Primary outcome | ||||||||
| Attainment of A1c goal (%, n) | ||||||||
| A1c < 7.0% | 31.9 (981) | 22.8 (249) | 36.9 (732) | < 0.001 | 28.5 (502) | 22.6 (199) | 34.4 (303) | < 0.001 |
| Other A1c outcomes | ||||||||
| Other follow-up A1c categories (%, n) | ||||||||
| A1c 7.0%-7.9% | 26.6 (818) | 28.6 (313) | 25.4 (505) | 0.060 | 27.2 (478) | 26.7 (235) | 27.6 (243) | 0.708 |
| A1c 8.0%-8.9% | 18.5 (570) | 21.8 (238) | 16.7 (332) | 0.001 | 19.9 (350) | 21.6 (190) | 18.2 (160) | 0.083 |
| A1c ≥ 9.0% | 23.0 (709) | 26.8 (293) | 21.0 (416) | < 0.001 | 24.4 (430) | 29.1 (256) | 19.8 (174) | < 0.001 |
| Overall A1c measurements (mean, SD) | ||||||||
| Baseline A1c | 9.6 (1.7) | 9.3 (1.5) | 9.8 (1.8) | < 0.001 | 9.4 (1.6) | 9.3 (1.5) | 9.4 (1.7) | 0.089 |
| Follow-up A1c | 8.0 (1.8) | 8.2 (1.8) | 7.8 (1.8) | < 0.001 | 8.1 (1.8) | 8.3 (1.8) | 7.8 (1.7) | < 0.001 |
| Change in A1c | -1.6 (2.4) | -1.1 (2.2) | -2.0 (2.4) | < 0.001 | -1.3 (2.2) | -1.0 (2.2) | -1.6 (2.2) | < 0.001 |
| Time of last follow-up A1c, months (mean [SD]) | 8.4 (1.7) | 8.4 (1.8) | 8.4 (1.7) | 0.972 | 8.4 (1.7) | 8.4 (1.8) | 8.3 (1.7) | 0.427 |
| Last follow-up A1c ≥ 9 months after index date (%, n) | 35.5 (1,093) | 35.1 (384) | 35.7 (709) | 0.775 | 35.3 (621) | 35.6 (313) | 35.0 (308) | 0.842 |
aP values for statistical significance were obtained using independent Student’s t-tests for continuous variables or Mann-Whitney U or chi-squared tests for categorical variables, as appropriate; bolded P values indicate statistical significance.
A1c = hemoglobin A1c; SD = standard deviation.