TABLE 1.

Demographic Results for the Study Cohorts

Subscriber Characteristics	Fully Insured					Self-Insured
	All Subscribers	All Families Cohort	P Valuea	Families with a Rare Disease Cohort	P Valuea	All Subscribers	All Families Cohort	P Valueb	Families with a Rare Disease Cohort	P Valueb
Observations, n (%)	39,274,850	9,904,563 (25.2)		9,117 (0.1)		19,621,014	6,111,514 (31.1)		6,904 (0.1)
Observation months, n	860,267,578	262,736,479		322,336		725,056,027	274,254,793		410,601
Average age of subscriber,c years	41.7 years	39.5 years	< 0.0001	39.6 years	0.78	42.5 years	40.0 years	< 0.0001	40.5 years	< 0.0001
Male, n (%)	21,169,144 (53.9)	6,031,879 (60.9)	< 0.0001	6,081 (66.7)	< 0.0001	10,497,243 (53.5)	3,636,350 (59.5)	< 0.0001	4,592 (66.5)	< 0.0001
Include spouse on coverage, n (%)	13,314,174 (33.9)	6,804,435 (68.7)	< 0.0001	7,111 (78.0)	< 0.0001	8,378,172 (42.7)	4,412,513 (72.2)	< 0.0001	5,688 (82.4)	< 0.0001
Average number of dependents aged ≤ 16,d years	0.5	1.8	< 0.0001	2.1	< 0.0001	0.6	1.8	< 0.0001	2.2	< 0.0001
0 (%)	74.8	0.0		0.0		68.9	0.0		0.0
1 (%)	11.5	45.8		29.8		13.6	43.7		26.9
2 (%)	9.2	36.3		41.1		11.6	37.3		42.1
3+ (%)	4.5	17.9		29.2		5.9	19.0		31.0

^aThe P value is the result of the comparison of the all subscribers cohort to the all families cohort.

^bThe P value is the result of the comparison of the all families cohort to the families with a rare disease cohort.

^cThe average age of each subscriber was calculated during their exposure period. The value reported in the table represents the average age for all subscribers in each cohort.

^dThe maximum number of child dependents observed during the subscriber exposure period was associated with each subscriber. The value reported in this table represents the average number of child dependents assigned to subscribers in each cohort.