Subscriber Characteristics	Hunter	Pompe	Gaucher	SMA	PKU	CF	MD
Fully insured cohort
Observations, n (%)	294 (3.2)	473 (5.2)	552 (6.1)	630 (6.9)	1,629 (17.9)	3,911 (42.9)	1,850 (20.3)
Observation months, n	10,504	16,772	23,196	22,899	60,355	128,011	70,907
Average age of subscriber, years	39.7	39.0	40.5	40.0	36.4	39.7	41.9
Male, n (%)	219 (74.4)	306 (64.7)	338 (61.2)	439 (69.7)	1,109 (68.1)	2,573 (65.8)	1,239 (67.0)
Include spouse on coverage, n (%)	239 (81.3)	362 (76.5)	427 (77.4)	521 (82.7)	1,274 (78.2)	3,000 (76.7)	1,461.5 (79.0)
Average number of dependents aged ≤ 16 years	2.2	2.2	2.1	2.1	2.2	2.1	2.2
0 (%)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
1 (%)	27.6	27.1	29.9	33.0	30.2	30.2	28.9
2 (%)	41.8	43.6	42.0	37.8	36.7	42.8	40.3
3+ (%)	30.6	29.4	28.1	29.2	33.1	27.0	30.7
Self-insured cohort
Observations, n (%)	219 (3.2)	403 (5.8)	440 (6.4)	502 (7.3)	1,146 (16.6)	2,901 (42.0)	1,526 (22.1)
Observation months, n	13,786	25,384	29,699	30,355	64,733	165,771	98,825
Average age of subscriber, years	41.0	41.1	41.2	40.8	37.2	40.6	42.7
Male, n (%)	164 (74.9)	263 (65.2)	298 (67.8)	327 (65.1)	733 (64.0)	1,923 (66.3)	1,036 (67.9)
Include spouse on coverage, n (%)	189 (86.3)	321 (79.7)	383 (87.0)	416 (82.9)	932 (81.3)	2,393 (82.5)	1,256 (82.3)
Average number of dependents aged ≤ 16 years	2.2	2.3	2.2	2.2	2.2	2.2	2.3
0 (%)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
1 (%)	26.0	27.5	24.8	26.1	26.7	27.0	26.7
2 (%)	46.6	40.4	44.8	42.2	41.2	42.6	41.3
3+ (%)	27.4	32.0	30.5	31.7	32.1	30.3	32.0

CF = cystic fibrosis; MD = muscular dystrophy; PKU = phenylketonuria; SMA = spinal muscular atrophy.