. 2018 Dec;24(12):10.18553/jmcp.2018.24.12.1250. doi: 10.18553/jmcp.2018.24.12.1250

TABLE 2.

Seriousness of DTPs as a Surrogate for a Utility in a Prescriber’s Decision

	Status Known^a	Accept (%)	Reject (%)	OR (95% CI)	P Value	Cohen’s Kappa Coefficient^b
All
Serious DTPs	41	15 (36.6)	26 (63.4)	1.95 (1.00-3.84)	0.05	0.08
Less serious DTPs	448	102 (22.8)	346 (77.2)	1.95 (1.00-3.84)	0.05	0.08
PGxMTM group only
Serious DTP	13	6 (46.2)	7 (53.8)	2.39 (0.71-8.01)	0.15	0.14
Less serious DTPs	72	19 (26.4)	53 (73.6)	2.39 (0.71-8.01)	0.15	0.14

^aAcceptance of 489 DTPs (of 1,054 total) was known. Analysis included the 489 DTPs.

^bKappa: inter-rater reliability, agreement between serious DTPs (i.e., grade 3 or above) flagged by pharmacists and acceptance of DTPs in a prescription.

CDST = clinical decision support tool; CI = confidence interval; DTPs = drug therapy problems; MTM = medical therapy management; OR = odds ratio; PGx = pharmacogenetics;

PGxMTM = MTM supported by PGx information and CDST.