TABLE 2.
Clinical Characteristics of Women with Endometriosis Who Initiated LA
| LA Plus Add-Back: NETA | LA Plus Add-Back: Other Therapies | LA Only | P Value for LA Plus NETA vs. LA Plus Other | P Value for LA Plus NETA vs. LA Only | ||||
|---|---|---|---|---|---|---|---|---|
| n = 470 | n = 681 | n = 1,963 | ||||||
| % | n | % | n | % | n | |||
| Mean [SD] Deyo CCI | 0.2 | [0.6] | 0.2 | [0.6] | 0.3 | [0.7] | 0.932 | 0.472 |
| Comorbid conditions | ||||||||
| Anxiety | 10.0 | 47 | 8.7 | 59 | 7.4 | 146 | 0.441 | 0.065 |
| Depression | 9.6 | 45 | 9.8 | 67 | 7.8 | 154 | 0.882 | 0.219 |
| Dysmenorrhea | 14.5 | 68 | 14.2 | 97 | 12.5 | 245 | 0.915 | 0.248 |
| Excessive or frequent menstruation | 12.6 | 59 | 11.5 | 78 | 17.3 | 339 | 0.571 | 0.013 |
| Unspecified symptoms of female genital organs | 42.3 | 199 | 40.5 | 276 | 36.7 | 720 | 0.539 | 0.023 |
| Abdominal/pelvic pain | 35.3 | 166 | 32.9 | 224 | 32.0 | 628 | 0.393 | 0.167 |
| Medications | ||||||||
| NSAIDs | 40.0 | 188 | 40.2 | 274 | 36.6 | 718 | 0.936 | 0.168 |
| Opioids | 55.5 | 261 | 54.5 | 371 | 50.4 | 990 | 0.724 | 0.047 |
| Androgens | 0.9 | 4 | 1.3 | 9 | 0.4 | 7 | 0.458 | 0.151 |
| Antidepressants | 33.2 | 156 | 33.2 | 226 | 27.5 | 539 | 0.999 | 0.013 |
| Hormonal contraceptives | 27.0 | 127 | 64.2 | 437 | 22.8 | 448 | < 0.001 | 0.054 |
| Hormone-releasing IUD or implant | 0.4 | 2 | 0.7 | 5 | 0.8 | 16 | 0.508 | 0.376 |
| Depot medroxyprogesterone | 4.7 | 22 | 2.1 | 14 | 4.4 | 87 | 0.012 | 0.815 |
| Other progestinsa | 28.3 | 133 | 12.9 | 88 | 8.4 | 164 | < 0.001 | < 0.001 |
a Noncontraceptive norethindrone, noncontraceptive medroxyprogesterone, and progesterone.
CCI = Charlson Comorbidity Index; IUD = intrauterine device; LA = leuprolide acetate; NETA = norethindrone acetate; NSAIDs = nonsteroidal anti-inflammatory drugs;
SD = standard deviation.