TABLE 3.

Adherence and Persistence with LA (6 Months) and Time to Surgery (12 Months) Following LA Initiation Among Women with Endometriosis

	LA Plus Add-Back: NETA		LA Plus Add-Back: Other Therapies		LA Only		P Value for LA Plus NETA vs. LA Plus Other	P Value for LA Plus NETA vs. LA Only
	n = 470		n = 681		n = 1,963
	%	n	%	n	%	n
Persistence
Discontinued during 6 months	37.9	178	40.2	274	59.6	1,169	0.420	< 0.001
Restarted LAa	18.5	33	13.5	37	7.8	91	0.148	< 0.001
Mean [SD] days persistent during 6 months	139	[56.0]	136	[57.4]	111	[62.3]	0.356	< 0.001
Adherence
Mean [SD] PDC during 6 months	0.70	[0.27]	0.68	[0.28]	0.56	[0.30]	0.398	< 0.001
PDC ≥ 80	47.2	222	47.9	326	31.5	619	0.193	< 0.001
Endometriosis-related surgery
Had surgery	12.6	59	16.9	115	16.9	332	0.044	0.021
Laparotomy	0.9	4	0.3	2	1.0	19	0.197	0.814
Laparoscopy	3.6	17	5.3	36	4.0	79	0.184	0.684
Other excision/ablation/fulguration	4.5	21	5.4	37	5.2	103	0.462	0.490
Oophorectomy	1.7	41	12.2	83	12.2	239	0.062	0.035
Mean [SD] days to endometriosis-related surgery, among those who had surgery	185	[86.4]	167	[94.7]	139	[94.9]	0.217	0.001
Mean [SD] days to laparotomy	151	[89.2]	250	[115.3]	169	[111.8]	0.301	0.762
Mean [SD] days to laparoscopy	161	[105.4]	181	[102.4]	155	[92.0]	0.502	0.814
Mean [SD] days to other excision/ablation/fulguration	165	[96.5]	185	[103.9]	146	[96.7]	0.476	0.408
Mean [SD] days to oophorectomy	195	[41.0]	170	[97.7]	144	[79.2]	0.500	0.086
Mean [SD] days to hysterectomy	189	[81.2]	153	[89.3]	137	[94.3]	0.032	0.001

^a Denominator is the number of patients who discontinued LA.

LA = leuprolide acetate; NETA = norethindrone acetate; PDC = proportion of days covered; SD = standard deviation.