|
Central Nervous System
|
| Cognitive impairment |
| Delirium |
| Depression |
| Disordered sleep |
| Myoclonus |
| Sedation |
| Somnolence |
|
Respiratory System
|
| Apnea |
| Ataxic breathing |
| Central sleep apnea |
| Hypercapnia |
| Hypoxia |
| Obstructive sleep apnea |
| Respiratory arrest and death |
| Respiratory depression |
|
Cardiovascular System
|
| Bradycardia |
| Cardiovascular event risk |
| Orthostatic hypotension |
| Vasodilatation |
|
Gastrointestinal System
|
| Abdominal cramping |
| Abdominal distention |
| Constipation |
| Delayed gastric emptying |
| Gastric reflux |
| Intestinal antisecretory activity |
| Nausea/vomiting |
|
Endocrine System
|
| Decreased androstendedione |
| Decreased dehydroepiandosterone sulfate |
| Decreased libido |
| Decreased testosterone |
| Early menopause |
| Sexual dysfunction |
| Testicular atrophy |
|
Immune System
|
| Altered cytokine production |
| Increased histamine release |
| Increased HIV replication |
| Inhibition of macrophage and natural killer cell activity and recruitment |
| Pruritus |
| Reduced wound healing |
