TABLE 1.
Projected Outcomes of PRIDE Trial Patients onto the Medicaid Patient Sample
| Outcomes | PRIDE Trial (Observed) a | Medicaid (Observed) a | PRIDE Trials (Projected) b | ||||||
|---|---|---|---|---|---|---|---|---|---|
| OA n = 212 | PP1M n = 219 | Difference | P Value (95% CI) | OA n = 4,609 | OA n = 212 | PP1M n = 219 | Difference | P Value (95% CI) | |
| Hospitalizations over 18 months (full sample), n | |||||||||
| AC, mean (SE) | 0.55 (0.15) | 0.37 (0.09) | 0.18 (0.18) | 0.317 (-0.17-0.53) | 0.83(0.04) | 0.59 (0.28) | 0.40 (0.15) | 0.19 (0.32) | 0.552 (-0.43-0.82) |
| Psych, mean (SE) | 0.42 (0.15) | 0.22(0.07) | 0.20 (0.18) | 0.267 (-0.15-0.55) | 0.50 (0.03) | 0.50 (0.28) | 0.24 (0.09) | 0.26 (0.29) | 0.370 (-0.31-0.83) |
| Among patients who discontinued by 6 months | |||||||||
| AC, mean (SE) | – | – | – | 1.01 (0.05) | – | – | – | ||
| Psych, mean (SE) | – | – | – | 0.64 (0.06) | – | – | – | ||
| Hospitalizations over 6 months (full sample), n | |||||||||
| AC, mean (SE) | 0.42 (0.13) | 0.19 (0.05) | 0.23 (0.15) | 0.125 (-0.06-0.52) | 0.64 (0.02) | 0.44 (0.17) | 0.13(0.04) | 0.31 (0.17) | 0.068 (-0.02-0.64) |
| Psych, mean (SE) | 0.37 (0.13) | 0.11(0.04) | 0.26 (0.14) | 0.063 (-0.01-0.53) | 0.38 (0.03) | 0.38 (0.16) | 0.08(0.04) | 0.30 (0.16) | 0.061 (-0.01-0.61) |
| Among patients who discontinued by 6 months | |||||||||
| AC, mean (SE) | – | – | – | 0.72 (0.03) | – | – | – | ||
| Psych, mean (SE) | – | – | – | 0.44 (0.02) | – | – | – | ||
| Probability of continuation ≥ 6 months | 0.47 (0.03) | 0.59 (0.03) | -0.12(0.04) | 0.003 (-0.20-0.04) | 0.39 (0.01) | 0.46 (0.05) | 0.60(0.04) | -0.14 (0.06) | 0.020 (-0.02-0.26) |
| Time to discontinuation over 15 months, days | |||||||||
| Full sample, mean (SE) | 155 (13) | 245 (19) | -90 (23) | < 0.001 (45-135) | 149(7) | 153 (17) | 240 (23) | -87 (29) | 0.003 (-30-144) |
| Among patients who did not discontinue by 6 months, mean (SE) | – | – | – | 374 (6) | – | – | – | ||
| Time to discontinuation over 18 months, days | |||||||||
| Full sample, mean (SE) | – | – | – | 154(7) | – | – | – | ||
| Among patients who did not discontinue by 6 months, mean (SE) | – | – | – | 400 (6) | – | – | – | ||
Note: A dash means not enough sample size for estimation.
aAdjusted for censoring.
bAdjusted for censoring and projected to reflect the Medicaid sample; standard errors obtained via 1,000 bootstrap replicates.
AC = all-cause; CI = confidence interval; OA = oral antipsychotic; PP1M = once-monthly long-acting injectable paliperidone palmitate; Psych = psychiatric; SE = standard error.