TABLE 1.
General Description of Patient Cohort Treated with Statins, Grouped by Whether LDL-C Threshold < 100 mg per dL Was Met or Not
| Demographics | Patients with LDL-C < 100 mg per dL n (%) | Patients with LDL-C ≥ 100 mg per dL n (%) | P Valuea |
|---|---|---|---|
| Total | 59,184 (66.3) | 30,083 (33.7) | – |
| Age | |||
| Mean, (SD) | 68 (10.8) | 64 (10.7) | < 0.001 |
| 45-54 | 7,667 (13.0) | 6,819 (22.7) | < 0.001 |
| 55-64 | 14,037 (23.7) | 8,735 (29.0) | |
| 65-74 | 21,317 (36.0) | 9,445 (31.4) | |
| ≥ 75 | 16,163 (27.3) | 5,084 (16.9) | |
| Gender | |||
| Female | 29,036 (49.1) | 18,891 (62.8) | < 0.001 |
| Male | 30,148 (50.9) | 11,192 (37.2) | |
| Ethnicity | |||
| Black | 3,299 (5.6) | 2,601 (8.7) | < 0.001 |
| Other | 2,935 (5.0) | 1,554 (5.2) | |
| White | 52,607 (89.4) | 25,655 (86.1) | |
| Missing | 343 | 273 | – |
| Clinical and laboratory characteristics | |||
| Triglyceride | |||
| Mean (SD) | 146 (26.2) | 208 (34.2) | < 0.001 |
| Missing | 2,385 | 1,816 | |
| Systolic blood pressure | |||
| Mean (SD) | 129 (17.8) | 131 (18.6) | < 0.001 |
| Missing | 48,590 | 24,727 | – |
| Smokingb | |||
| 12,316 (32.1) | 6,101 (33.7) | < 0.001 | |
| Missing | 20,793 | 11,993 | – |
| Aspirin | |||
| Beforec | 19,002 (32.1) | 7,257 (24.1) | < 0.001 |
| Afterc | 27,092 (45.8) | 11,267 (37.5) | < 0.001 |
| Antihypertensive treatment | |||
| Beforec | 29,389 (49.7) | 12,684 (42.2) | < 0.001 |
| Afterc | 39,249 (66.3) | 16,705 (55.5) | < 0.001 |
| Compliance with statin regimen (MPR ≥ 80%) | |||
| 39,113 (66.1) | 12,125 (40.3) | < 0.001 | |
| Missing | 14 (before index date) | 5 (after index date) | – |
| Intensity of initial statin regimen | |||
| High | 11,767 (19.9) | 4,003 (13.3) | < 0.001 |
| Moderate | 42,636 (72.0) | 22,669 (75.4) | |
| Low | 4,781 (8.1) | 3,411 (11.3) | |
| Health conditions | |||
| Diabetes-afterc | 20,278 (34.3) | 7,051 (23.4) | < 0.001 |
| Congestive heart failure | 6,726 (11.4) | 1,873 (6.2) | < 0.001 |
| PAD | 4,051 (6.8) | 1,330 (4.4) | < 0.001 |
| Stroke | 4,392 (7.4) | 1,577 (5.2) | < 0.001 |
| Prior MI | 6,102 (10.3) | 1,806 (6.0) | < 0.001 |
Note: All values in this table are n (%) unless indicated otherwise.
aP values denote the statistical significance of differences for values within rows.
bSmoking was mentioned in clinical notes before and up to the index date.
cMissing days-of-supply data.
LDL-C = low-density lipoprotein cholesterol; MI= myocardial infarction; MPR = medication possession ratio; PAD = peripheral artery disease; SD = standard deviation.