TABLE 4.

Contextual Considerations

Are any of the following contextual considerations important in assessing the long-term value for money of dupilumab versus standard of care without biologics?
Contextual Consideration	Panel Votesa
Dupilumab is intended for the care of individuals with a condition of particularly high severity in terms of impact on length of life and/or quality of life	11
Dupilumab is intended for the care of individuals with a condition that represents a particularly high lifetime burden of illness.	12
Dupilumab is the first to offer any improvement for patients with this condition	0
There is significant uncertainty about the long-term risk of serious side effects of this intervention.	8
There is significant uncertainty about the magnitude or durability of the long-term benefits of this intervention.	11
There are additional contextual considerations that should have an important role in judgements of the value of this intervention	3

^aFifteen panelists voted.