TABLE 4.
Incident Comorbidities
| IC (n = 24,836) | Non-IC (n = 99,344) | Adjusted Ratioa | |
|---|---|---|---|
| % (n) | % (n) | OR (95% CI) | |
| Any comorbidity | 24.2 (6,008) | 10.7 (10,650) | 2.61 (2.52-2.70)b |
| Anxiety | 9.0 (1,882) | 4.0 (3,675) | 2.35 (2.22-2.49)b |
| Chronic fatigue | 0.9 (209) | 0.3 (287) | 2.85 (2.38-3.41)b |
| Depression | 5.2 (1,181) | 2.4 (2,240) | 2.22 (2.07-2.39)b |
| Fibromyalgia | 6.4 (1,433) | 2.1 (2,030) | 3.11 (2.90-3.34)b |
| Insomnia | 3.4 (804) | 1.5 (1,493) | 2.22 (2.03-2.42)b |
| IBS | 3.6 (843) | 0.8 (751) | 4.80 (4.34-5.30)b |
| Migraine headaches | 4.2 (956) | 1.8 (1,729) | 2.39 (2.20-2.59)b |
| Sicca syndrome | 0.3 (85) | 0.1 (95) | 3.43 (2.56-4.60)b |
| Vulvodynia | 0.9 (212) | 0.0 (34) | 25.69 (17.88-36.93)b |
| HL (n = 292) |
Non-HL
(n = 24,544) |
Adjusted Ratioa | |
| % (n) | % (n) | OR (95% CI) | |
| Any comorbidity | 22.6 (66) | 24.2 (5,942) | 0.95 (0.72-1.25) |
| Anxiety | 7.1 (17) | 9.0 (1,865) | 0.80 (0.49-1.32) |
| Chronic fatigue | 0.4 (3) | 0.9 (206) | 1.24 (0.39-3.93) |
| Depression | 7.2 (19) | 5.2 (1,162) | 1.47 (0.92-2.35) |
| Fibromyalgia | 5.2 (14) | 6.4 (1,419) | 0.82 (0.48-1.42) |
| Insomnia | 2.5 (7) | 3.4 (797) | 0.74 (0.35-1.58) |
| IBS | 4.7 (13) | 3.6 (830) | 1.36 (0.77-2.39) |
| Migraine headaches | 2.3 (6) | 4.2 (950) | 0.55 (0.25-1.25) |
| Sicca syndrome | 0.3 (1) | 0.3 (84) | 0.97 (0.13-7.08) |
| Vulvodynia | 0.7 (2) | 0.9 (210) | 0.85 (0.21-3.42) |
aAdjusted for baseline age, sex, region, and Charlson Comorbidity Index.
bP value ≤ 0.001.
CI = confidence interval; HL = Hunner’s lesions; IBS = irritable bowel syndrome; IC = interstitial cystitis; OR = odds ratio.