TABLE 2.

Ribociclib Tablets or Palbociclib Capsules Surplus or Wasted Due to Dose Reduction

	Ribociclib Dose Change			Palbociclib Dose Change
	600 mg to 400 mg	600 mg to 200 mg	400 mg to 200 mg	125 mg to 100 mg	125 mg to 75 mg	100 mg to 75 mg
Initial daily dose at start of cycle	600 mg	600 mg	400 mg	125 mg	125 mg	100 mg
Daily dose after change	400 mg	200 mg	200 mg	100 mg	75 mg	75 mg
Day in cycle dose reduction	Day 14	Day 14	Day 14	Day 14	Day 14	Day 14
Number of tablets/capsules dispensed	63	63	42	21	21	21
Number of tablets/capsules used before dose change at day 14	42	42	28	14	14	14
Number of tablets/capsules needed for remainder of cycle	14	7	7	7	7	7
Number of 200 mg tablets surplus by adjusting for dose change	7	14	7
Number of capsules wasted by adjusting for dose change				7	7	7