TABLE 3.
Propensity Score Weight-Adjusted ORs and Associated 95% CIs from Logistic Regression Models,a Persistence and Compliance (Defined with a 60-Day Gap Allowance) with Index Therapy over 12 Months
| Persistence | 95% CI | Compliance | 95% CI | |||
|---|---|---|---|---|---|---|
| OR | Lower | Upper | OR | Lower | Upper | |
| Denosumab vs. alendronate | 4.17 | 3.69 | 4.83 | 5.88 | 5.10 | 6.71 |
| Denosumab vs. ibandronate | 4.55 | 3.85 | 5.29 | 6.25 | 5.21 | 7.25 |
| Denosumab vs. risedronate | 5.56 | 4.78 | 6.76 | 7.69 | 6.54 | 9.26 |
| Denosumab vs. raloxifene | 3.13 | 2.61 | 3.80 | 4.35 | 3.52 | 5.15 |
| Denosumab vs. teriparatide | 1.59 | 1.23 | 2.04 | 2.44 | 1.92 | 3.17 |
aModels adjusted for age, health plan type, U.S. Census region, urban residency, patient out-of-pocket expenditure for the index therapy, and the following baseline/preindex clinical characteristics: Charlson Comorbidity Index score; number of unique medications prescribed; and diagnosis of osteoporosis, osteopenia, renal insufficiency, gastrointestinal disorders, coronary heart disease, and osteoporosis-related fracture.
CI = confidence interval; OR = odds ratio.