TABLE 4.
Persistence (30-Day Gap Allowance) | 95% CI | Persistence (90-Day Gap Allowance) | 95% CI | |||
---|---|---|---|---|---|---|
OR | Lower | Upper | OR | Lower | Upper | |
Denosumab vs. alendronate | 5.10 | 4.48 | 5.85 | 4.00 | 3.48 | 4.61 |
Denosumab vs. ibandronate | 5.68 | 4.81 | 6.67 | 3.82 | 3.25 | 4.48 |
Denosumab vs. risedronate | 6.67 | 5.56 | 7.94 | 5.32 | 4.48 | 6.33 |
Denosumab vs. raloxifene | 3.18 | 2.64 | 3.85 | 2.87 | 2.37 | 3.46 |
Denosumab vs. teriparatide | 1.83 | 1.43 | 2.35 | 1.15 | 1.16 | 1.96 |
aModels adjusted for age, health plan type, U.S. Census region, urban residency, patient out-of-pocket expenditure for the index therapy, and the following baseline/preindex clinical characteristics: Charlson Comorbidity Index score; number of unique medications prescribed; and diagnosis of osteoporosis, osteopenia, renal insufficiency, gastrointestinal disorders, coronary heart disease, and osteoporosis-related fracture.
CI = confidence interval; OR = odds ratio.