TABLE 1.

Definitions of Previous Adherence Measures

Measurement Type	Measurement Name	Definition
Measures based on prescription coverage days	Continuous measure of medication acquisition (CMA)	Numerator: total days supply dispensed during denominator Denominator: time between first dispensation in baseline period and the end of baseline period (date of statin initiation)
	Continuous measure of medication gaps (CMG)	Numerator: total gap days (number of days without medication days supply) Denominator: time between first dispensation in baseline period and end of baseline period
	Proportion of days covered (PDC)	Numerator: total days supply capped at maximum of number of days in denominators Denominator: time between first dispensation in baseline period and the end of baseline period
Measures based on discontinuation	Discontinuation(dichotomous;DD)	Presence (yes = 1 or no = 0) of 1 or more periods of at least 30 days without medication supply following the days supply of a dispensation in baseline period
	Time to discontinuation(TTD)	Days between date of first dispensation and discontinuation or the end of baseline period
Measures based on dispensation counts	Refill counts (counts)	Number of dispensations in baseline period beyond first fill for each drug
	Lack of second fills (dichotomous)	Not having a second dispensation of a drug in baseline period when the first dispensation occurred more than 30 days + days supply before the statin initiation