TABLE 4.
C-statistics from Models Predicting High Statin Adherence (PDC ≥80%) Based on Previous Adherence Measured Using Only Specific Medication Classes, Applied to Various Testing Cohorts
| Medication Group | Drugs/Classes Included | Among Patients with Previous Adherence Measure for the Specific Medication Group | Among All Patients in the Primary Analysis Cohorta | Among Patients in the Expanded Cohort Including Patients with No Previous Use of Medications for Adherence Measurementa | |||
|---|---|---|---|---|---|---|---|
| n | C-statisticsb (95% CI) | n | C-statisticsb (95% CI) | n | C-statisticsb (95% CI) | ||
| All medications | See Appendix B for full list | - | - | 44,745 | 0.695 (0.690-0.700) | 82,810 | 0.676 (0.672-0.679) |
| Antihypertensives | ACEI/ARBs, diuretics, DHP-CCB | 27,912 | 0.692 (0.686-0.698) | 44,745 | 0.682 (0.677-0.687) | 82,810 | 0.669 (0.665-0.673) |
| Antidiabetics | Metformin, sulfonylurea | 8,952 | 0.720 (0.709-0.731) | 44,745 | 0.671 (0.666-0.676) | 82,810 | 0.663 (0.659-0.667) |
| Lipid-lowering drugs other than statins | Fibrates, bile acid sequestrants, ezetimibe | 2,196 | 0.717 (0.695-0.739) | 44,745 | 0.669 (0.663-0.674) | 82,810 | 0.661 (0.657-0.665) |
| SSRIs | SSRIs | 9,140 | 0.665 (0.653-0.676) | 44,745 | 0.669 (0.664-0.674) | 82,810 | 0.661 (0.657-0.665) |
aPatients without previous adherence measure for the specific medication group were given a median adherence value from the training cohort.
bAll models included baseline information variables from table 2 + mean PDC.
ACEI = angiotensin-converting enzyme inhibitors, ARBs = angiotensin II receptor blockers; c-statistics = concordance statistics; CI = confidence interval; DHP-CCB = dihydropyridine calcium channel blockers; PDC = proportion of days covered, SSRI = selective serotonin reuptake inhibitors.