#1 rheumatoid arthritis

#2 antirheumatic agent

#3 (#1 AND #2)

#4 adalimumab OR Humira

#5 infliximab OR Remicade

#7 golimumab OR Simponi OR CNTO 148

#8 certolizumab OR Cimzia OR CDP870

#9 tocilizumab OR Actemra OR RoActemra

#10 rituximab OR Rituxan OR Mabthera

#11 abatacept OR Orencia

#12 anakinra OR Kineret

#13 (tofacitinib or tasocitinib or CP-690550).ti,ab.

#14 tumor necrosis factor OR tumor necrosis factor inhibitor OR tumor necrosis factor blocker OR tumor necrosis factor receptor OR anti-tumor necrosis factor OR TNF OR anti-TNF

#15 biologic OR biological

#16 (#4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15)

#17 randomized controlled trial OR randomized-controlled-trial OR controlled-clinical-trial OR randomized OR clinical trial OR random OR RCT OR random allocation OR double-blind method OR single-blind method OR placebo

#18 (#3 AND #16 AND #17)

#19 Limit #18 to Humans, Adults, and the years 1990-2011