| Type of Encounter | Median (IQR) Cost per Patient per Year, Anti-CCP Positive, $ | Median (IQR) Cost per Patient per Year, Anti-CCP Negative, $ | ||
|---|---|---|---|---|
| Office visit | ||||
| Baseline (N = 2,448) | 517.90 (247.50-960.70) | 647.10 (338.0-1,190.40) | ||
| 1 year (n = 2,448) | 882.80 (497.20-1,388.00) | 996.80 (594.10-1,566.90) | ||
| 2 years (n = 1,882) | 1,158.12 (615.31-2,044.03) | 1,494.14 (768.08-2,839.53) | ||
| 3 years (n = 1,466) | 1,203.85 (545.87-2,172.66) | 1,449.80 (772.21-2,899.98) | ||
| 4 years (n = 1,117) | 1,175.05 (538.05-2,209.84) | 1,637.33 (620.58-2,846.78) | ||
| 5 years (n = 809) | 1,249.65 (560.57-2,137.75) | 1,487.93 (677.75-2,594.53) | ||
| 6 years (n = 539) | 1,131.38 (529.09-2,164.75) | 1,367.96 (549.77-2,834.31) | ||
| 7 years (n = 278) | 1,198.84 (438.81-2,471.87) | 2,032.65 (758.44-3,660.19) | ||
| 8 years (n = 83) | 1,381.04 (645.52-2,285.39) | 1,619.92 (729.55-2,687.88) | ||
| Rheumatologist visit | ||||
| Baseline (N = 2,448) | 0.00 (0.00-120.20) | 80.7 (0.00-137.00) | ||
| 1 year (n = 2,448) | 321.00 (168.60-547.80) | 271.20 (129.90-440.30) | ||
| 2 years (n = 1,882) | 242.07 (80.69-522.86) | 129.94 (0.00-358.6) | ||
| 3 years (n = 1,466) | 238.83 (0.00-512.79) | 119.41 (0.00-322.76) | ||
| 4 years (n = 1,117) | 183.06 (49.17-445.26) | 84.94 (0.00-358.24) | ||
| 5 years (n = 809) | 161.38 (0.00-442.17) | 80.69 (0.00-295.60) | ||
| 6 years (n = 539) | 138.72 (0.00-410.75) | 49.17 (0.00-200.10) | ||
| 7 years (n = 278) | 119.78 (0.00-370.87) | 14.55 (0.00-329.35) | ||
| 8 years (n = 83) | 119.41 (0.00-390.68) | 13.59 (0.00-238.83) | ||
| Laboratory | ||||
| Baseline (N = 2,448) | 519.00 (324.4-796.30) | 614.80 (378.80-922.80) | ||
| 1 year (n = 2,448) | 902.00 (553.5-1,339.70) | 822.10 (456.2-1,239.90) | ||
| 2 years (n = 1,882) | 753.86 (443.31-1,124.30) | 697.65 (394.41-1,122.03) | ||
| 3 years (n = 1,466) | 773.64 (439.70-1,148.00) | 695.62 (386.55-1,025.33) | ||
| 4 years (n = 1,117) | 750.80 (464.48-1,160.88) | 654.89 (416.48-1,043.57) | ||
| 5 years (n = 809) | 731.17 (465.83-1,090.01) | 642.82 (381.79-1,060.95) | ||
| 6 years (n = 539) | 728.93 (441.96-1,046.23) | 651.77 (344.95-1,056.78) | ||
| 7 years (n = 278) | 666.24 (431.93-1,015.33) | 771.50 (405.91-1,122.87) | ||
| 8 years (n = 83) | 682.83 (388.90-999.53) | 657.46 (336.84-1,175.39) | ||
| Prescriptions | ||||
| Baseline (N = 2,448) | 1,240.90 (350.90-3,385.50) | 2,268.60 (766.0-5,524.50) | ||
| 1 year (n = 2,448) | 3,755.60 (1,797.60-8,372.60) | 4,417.30 (2,072.30-8,268.00) | ||
| 2 years (n = 1,882) | 4,031.16 (1,533.02-10,017.44) | 4,268.08 (1,672.16-9,272.66) | ||
| 3 years (n = 1,466) | 4,521.10 (1,822.33-11,680.88) | 4,568.88 (2,112.35-10,234.34) | ||
| 4 years (n = 1,117) | 4,658.20 (1,870.50-12,113.94) | 4,944.90 (1,971.38-10,185.61) | ||
| 5 years (n = 809) | 4,897.47 (1,803.27-13,181.51) | 5,455.41 (2,290.35-10,483.17) | ||
| 6 years (n = 539) | 5,076.84 (1,876.44-15,606.44) | 5,377.84 (2,267.92-10,430.39) | ||
| 7 years (n = 278) | 5,020.76 (2,077.40-12,385.97) | 5,729.22 (2,189.79-11,441.58) | ||
| 8 years (n = 83) | 6,404.45 (3,243.31-12,474.58) | 6,551.35 (1,713.07-20,308.92) | ||
| Total | ||||
| Baseline (N = 2,448) | 2,798.40 (1,333.20-6,223.70) | 4,244.90 (2,030.70-9,332.30) | ||
| 1 year (n = 2,448) | 6,199.70 (3,563.20-13,259.70) | 7,022.10 (3,884.50-12,994.60) | ||
| 2 years (n = 1,882) | 7,126.22 (3,785.34-16,969.54) | 8,028.69 (3,977.41-16,553.91) | ||
| 3 years (n = 1,466) | 7,736.66 (4,226.74-20,516.61) | 8,680.23 (4,590.96-16,655.74) | ||
| 4 years (n = 1,117) | 8,370.77 (3,887.34-21,515.97) | 9,065.76 (4,738.44-17,265.75) | ||
| 5 years (n = 809) | 8,820.14 (4,005.57-21,778.83) | 9,224.12 (4,844.92-16,698.40) | ||
| 6 years (n = 539) | 9,462.65 (4,148.12-27,539.51) | 8,925.49 (4,137.93-18,262.83) | ||
| 7 years (n = 278) | 9,389.91 (4,535.64-23,026.08) | 10,135.41 (4,567.41-25,372.01) | ||
| 8 years (n = 83) | 10,959.97 (5,995.52-18,159.01) | 11,710.04 (3,848.51-26,335.88) | ||
a Costs are shown in 2015 U.S. dollars.
CCP = cyclic citrullinated peptide; IQR = interquartile range.