TABLE 1.

Epidemiology Parameters for a 1 Million-Member Hypothetical Health Care Plan

Model Population Parameter	Commercial Population		Medicare Advantage Population
	Frequency, %	Patients, n	Frequency, %	Patients, n
Hypothetical plan membership		1,000,000		1,000,000
Prevalence of chronic HF	1.0a	10,000	16.0b	160,000
Chronic HF patients with systolic chronic HF	52.9c	5,290	52.9c	84,640
With normal sinus rhythm	66.8d	3,534	66.8d	56,540
With normal sinus rhythm and NYHA Class II to IV	88.3d	3,120	88.3d	49,924
With normal sinus rhythm and NYHA Class II to IV with heart rate of ≥ 70 bpm	61.3e	1,913	61.3e	30,604
Incidence of chronic HF	0.1	1,000	3.1	31,000
Chronic HF patients with systolic chronic HF	52.9c	529	52.9c	16,399
With normal sinus rhythm	66.8d	353	66.8d	10,955
With normal sinus rhythm and NYHA Class II to IV	88.3d	312	88.3d	9,673
With normal sinus rhythm and NYHA Class II to IV with heart rate of ≥ 70 bpm	61.3e	191	61.3e	5,929
Total patients eligible for treatment (prevalent + incident populations)		2,104		36,533

^aChamberlain AM, Redfield MM, Alonso A, Weston SA, Roger VL. Atrial fibrillation and mortality in heart failure: a community study. ¹²

^bCenters for Medicare & Medicaid Services. Chronic conditions among Medicare beneficiaries. Chartbook: 2012 edition. ¹³

^cOwan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM. Trends in prevalence and outcome of heart failure with preserved ejection fraction. ¹⁴

^dFonarow GC, Albert NM, Curtis AB, et al. Improving evidence-based care for heart failure in outpatient cardiology practices: primary results of the Registry to Improve the Use of Evidence-Based Heart Failure Therapies in the Outpatient Setting (IMPROVE HF). ¹⁵

^eStudy of Anemia in a Heart Failure Population (STAMINA) registry (N = 1,090) from June 24, 2002, to July 11, 2003. bpm = beats per minute; HF = heart failure; NYHA = New York Heart Association.