Warfarin vs. Apixaban	P Value	Dabigatran vs. Apixaban	P Value	Rivaroxaban vs. Apixaban	P Value
Excluding patients with catheter ablation or cardioversion, HR (95% CI)
Stroke/SE	1.84 (1.03-2.59)	< 0.001	1.17 (0.68-2.03)	0.573	1.46 (1.08-1.98)	0.015
Major bleeding	1.53 (1.24-1.89)	< 0.001	1.76 (1.27-2.43)	< 0.001	1.59 (1.34-1.89)	< 0.001
Censoring at 6 months, HR (95% CI)
Stroke/SE	1.95 (1.26-3.01)	0.003	1.14 (0.58-2.23)	0.711	1.64 (1.13-2.39)	0.009
Major bleeding	1.70 (1.31-2.22)	< 0.001	1.81 (1.18-2.77)	0.006	1.85 (1.48-2.32)	< 0.001
Intent to treat, HR (95% CI)
Stroke/SE	1.58 (1.23-2.04)	< 0.001	1.18 (0.82-1.69)	0.387	1.57 (1.25-1.96)	< 0.001
Major bleeding	1.34 (1.14-1.57)	< 0.001	1.35 (1.06-1.71)	0.015	1.38 (1.20-1.58)	< 0.001

CI = confidence interval; HR = hazard ratio; SE = systemic embolism.