TABLE 1.
Baseline Demographic and Clinical Characteristics by Index Prostaglandin Analog
| Number (Column %) | Total (N = 3,888) | Latanoprost (n = 1,296) | Travoprost (n = 1,296) | Bimatoprost (n = 1,296) | P Valuea (Latanoprost vs. Travoprost) | P Valuea (Latanoprost vs. Bimatoprost) | P Valuea (Travoprost vs. Bimatoprost) |
|---|---|---|---|---|---|---|---|
| Age, yearsb,c | |||||||
| Mean± SD | 74.4 ± 7.9 | 74.5 ± 7.9 | 74.3 ± 7.9 | 74.4 ± 8.0 | 0.533 | 0.629 | 0.880 |
| 40-65 | 255 (6.6) | 85 (6.6) | 85 (6.6) | 85 (6.6) | 1.000 | 1.000 | 1.000 |
| 66-75 | 1,753 (45.1) | 564 (43.5) | 603 (46.5) | 586 (45.2) | 0.098 | 0.333 | 0.474 |
| 76-85 | 1,601 (41.2) | 557 (43.0) | 505 (39.0) | 539 (41.6) | 0.025 | 0.433 | 0.151 |
| ≥ 86 | 279 (7.2) | 90 (7.0) | 103 (8.0) | 86 (6.6) | 0.312 | 0.749 | 0.183 |
| Genderc | |||||||
| Female | 2,138 (55.0) | 723 (55.8) | 696 (53.7) | 719 (55.5) | 0.156 | 0.240 | 0.831 |
| Male | 1,750 (45.0) | 573 (44.2) | 600 (46.3) | 577 (44.5) | |||
| Race/ethnicityc | |||||||
| White | 2,753 (70.8) | 922 (71.1) | 907 (70.0) | 924 (71.3) | 0.418 | 0.915 | 0.368 |
| Black | 930 (23.9) | 310 (23.9) | 314 (24.2) | 306 (23.6) | 0.798 | 0.803 | 0.623 |
| Hispanic | 112 (2.9) | 36 (2.8) | 41 (3.2) | 35 (2.7) | 0.553 | 0.901 | 0.486 |
| Others | 93 (2.4) | 28 (2.2) | 34 (2.6) | 31 (2.4) | 0.431 | 0.686 | 0.701 |
| Geographic regionc | |||||||
| Midwest | 834 (21.5) | 283 (21.8) | 281 (21.7) | 270 (20.8) | 0.910 | 0.463 | 0.535 |
| Northeast | 103 (2.7) | 35 (2.7) | 32 (2.5) | 36 (2.8) | 0.691 | 0.896 | 0.599 |
| South | 2,637 (67.8) | 870 (67.1) | 882 (68.1) | 885 (68.3) | 0.519 | 0.418 | 0.872 |
| West | 314 (8.1) | 108 (8.3) | 101 (7.8) | 105 (8.1) | 0.528 | 0.802 | 0.722 |
| CCI scoreb,c | |||||||
| Mean ± SD | 2.45 ± 2.3 | 2.4 ± 2.3 | 2.48 ± 2.3 | 2.48 ± 2.3 | 0.305 | 0.264 | 0.929 |
| 0 | 1,060 (27.3) | 361 (27.9) | 351 (27.1) | 348 (26.9) | 0.612 | 0.508 | 0.880 |
| 1 | 422 (10.9) | 155 (12.0) | 127 (9.8) | 140 (10.8) | 0.067 | 0.326 | 0.378 |
| 2 | 826 (21.2) | 257 (19.8) | 279 (21.5) | 290 (22.4) | 0.249 | 0.079 | 0.579 |
| 3 | 459 (11.8) | 171 (13.2) | 149 (11.5) | 139 (10.7) | 0.195 | 0.043 | 0.541 |
| 4 | 412 (10.6) | 119 (9.2) | 152 (11.7) | 141 (10.9) | 0.027 | 0.129 | 0.480 |
| ≥ 5 | 709 (18.2) | 233 (18.0) | 238 (18.4) | 238 (18.4) | 0.775 | 0.771 | 1.000 |
| Type of glaucomac | |||||||
| ACG | 23 (0.6) | 7 (0.5) | 8 (0.6) | 8 (0.6) | 0.796 | 0.796 | 1.000 |
| NTG | 204 (5.3) | 66 (5.1) | 69 (5.3) | 69 (5.3) | 0.756 | 0.756 | 1.000 |
| OAG | 2,845 (73.2) | 945 (72.9) | 947 (73.1) | 953 (73.5) | 0.912 | 0.659 | 0.750 |
| OHT/Other | 254 (6.5) | 78 (6.0) | 94 (7.3) | 82 (6.3) | 0.131 | 0.698 | 0.300 |
| Borderline glaucoma | 562 (14.5) | 200 (15.4) | 178 (13.8) | 184 (14.2) | 0.131 | 0.279 | 0.691 |
| Having ocular disorderc | |||||||
| Yes | 3,003 (77.2) | 1,007 (77.7) | 1,004 (77.5) | 992 (76.5) | 0.878 | 0.445 | 0.547 |
| No | 885 (22.8) | 289 (22.3) | 292 (22.5) | 304 (23.5) | |||
| Having hypertensionc | |||||||
| Yes | 2,937 (75.6) | 978 (75.5) | 979 (75.5) | 980 (75.6) | 0.959 | 0.919 | 0.959 |
| No | 951 (24.5) | 318 (24.5) | 317 (24.5) | 316 (24.4) | |||
| Having diabetesc | |||||||
| Yes | 1,424 (36.6) | 463 (35.7) | 473 (36.5) | 488 (37.7) | 0.613 | 0.219 | 0.455 |
| No | 2,464 (63.4) | 833 (64.3) | 823 (63.5) | 808 (62.4) | |||
| Pre-index number of all-cause outpatient visitsb | |||||||
| Mean ± SD | 0.8 ± 2.8 | 0.6 ± 2.5 | 0.8 ± 2.9 | 0.8 ± 2.9 | 0.998 | 0.445 | 0.413 |
| Pre-index all-cause inpatient visitsc | |||||||
| Yes | 571 (14.7) | 169 (13.0) | 204 (15.7) | 198 (15.3) | 0.038 | 0.077 | 0.733 |
| No | 3,317 (85.3) | 1,127 (87.0) | 1,092 (84.3) | 1,098 (84.7) | |||
aSignificant at P < 0.05 (in bold).
bPaired t-test.
cMcNemar’s test.
ACG = angle-closure glaucoma; CCI = Charlson Cormidity Index; NTG = normal tension glaucoma; OAG = open-angle glaucoma; OHT = ocular hypertension; SD = standard deviation.