TABLE 4.
Logistic Regression Comparing Odds of Adding or Switching in Second-Line Therapy
| Adding Alternative Medicationsa | Switching to Alternative Medicationsa | |||||
|---|---|---|---|---|---|---|
| Odds Ratio (95% CI) | Wald X2 | P Valueb | Odds Ratio (95% CI) | Wald X2 | P Valueb | |
| PGA type | ||||||
| Latanoprost (ref.) | – | – | – | – | – | – |
| Travoprost | 1.43 (1.10-1.86) | 5.50 | 0.019 | 0.96 (0.78-1.19) | 0.81 | 0.368 |
| Bimatoprost | 1.21 (0.92-1.58) | 0.01 | 0.923 | 0.79 (0.63-0.97) | 5.33 | 0.021 |
| Age (continuous) | 1.01 (0.99-1.02) | 0.86 | 0.353 | 1.00 (0.99-1.01) | 0.27 | 0.601 |
| Gender | ||||||
| Male (ref.) | – | – | – | – | – | – |
| Female | 0.99 (0.80-1.23) | 0.01 | 0.939 | 1.12 (0.94-1.34) | 1.59 | 0.208 |
| Race/ethnicity | ||||||
| White (ref.) | – | – | – | – | – | – |
| Nonwhite | 1.23 (0.97-1.56) | 2.97 | 0.085 | 0.81 (0.66-0.99) | 4.23 | 0.040 |
| Geographic region | ||||||
| Non-South (ref.) | – | – | – | – | – | – |
| South | 1.16 (0.91-1.48) | 1.44 | 0.230 | 1.29 (1.06-1.57) | 6.41 | 0.011 |
| CCI score (continuous) | 1.00 (0.99-1.00) | 0.94 | 0.331 | 1.00 (0.99-1.00) | 0.01 | 0.909 |
| Type of glaucoma | ||||||
| Non-OAG (ref.) | – | – | – | – | – | – |
| OAG | 1.56 (1.20-2.04) | 10.91 | 0.001 | 0.91 (0.75-1.11) | 0.87 | 0.350 |
| Ocular disorder | ||||||
| No (ref.) | – | – | – | – | – | – |
| Yes | 1.05 (0.81-1.35) | 0.13 | 0.721 | 1.23 (0.99-1.53) | 3.48 | 0.062 |
| Hypertension | ||||||
| No (ref.) | – | – | – | – | – | – |
| Yes | 0.91 (0.70-1.18) | 0.52 | 0.471 | 0.97 (0.78-1.20) | 0.10 | 0.751 |
| Diabetes | ||||||
| No (ref.) | – | – | – | – | – | – |
| Yes | 0.87 (0.68-1.12) | 1.15 | 0.283 | 0.96 (0.78-1.18) | 0.15 | 0.697 |
| Pre-index number of outpatient visits (continuous) | 1.00 (0.99-1.01) | 0.82 | 0.366 | 1.00 (0.99-1.01) | 0.42 | 0.518 |
| Pre-index inpatient visits | ||||||
| No (ref.) | – | – | – | – | – | – |
| Yes | 1.06 (0.77-1.47) | 0.14 | 0.705 | 1.06 (0.81-1.38) | 0.19 | 0.662 |
aConditional logistic regression model was used for adding alternative medications (Yes/No) and switching to alternative medications (Yes/No).
bSignificant at P < 0.05 (in bold).
CCI = Charlson Comorbidity Index; CI = confidence interval; OAG = open-angle glaucoma; PGA = prostaglandin analog; ref. = reference; X2 = chi-square.