| Medication | Addition Therapy, n (%) | Switch Therapy, n (%) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| All | Latanoprost | Travoprost | Bimatoprost | P Valuea | All | Latanoprost | Travoprost | Bimatoprost | P Valuea | |
| Total | 382 (100) | 107 (100) | 148 (100) | 127 (100) | 601 (100) | 216 (100) | 209 (100) | 176 (100) | ||
| Beta blockers | 132 (34.6) | 45 (42.1) | 48 (32.4) | 39 (30.7) | 0.151 | 168 (28.0) | 57 (26.4) | 61 (29.2) | 50 (28.4) | 0.803 |
| Timolol | 127 (33.3) | 44 (41.1) | 46 (31.1) | 37 (29.1) | 164 (27.3) | 56 (25.9) | 59 (28.2) | 49 (27.8) | ||
| Levobunolol | 2 (0.5) | 1 (0.9) | 1 (0.7) | 0 (0) | 3 (0.5) | 1 (0.5) | 2 (1.0) | 0 (0) | ||
| Betaxolol | 3 (0.8) | 0 (0.0) | 1 (0.7) | 2 (1.6) | 1 (0.2) | 0 (0.0) | 0 (0.0) | 1 (0.6) | ||
| PGAb | 26 (6.8) | 8 (7.5) | 10 (6.8) | 8 (6.3) | 0.938 | 226 (37.6) | 97 (44.9) | 73 (34.9) | 56 (31.8) | 0.018 |
| Latanoprost | 4 (1.1) | 0 (0.0) | 0 (0.0) | 4 (3.2) | 48 (8.0) | 0 (0.0) | 51 (24.4) | 30 (17.1) | ||
| Travoprost | 5 (1.3) | 1 (0.9) | 0 (0.0) | 4 (3.2) | 62 (10.3) | 65 (30.2) | 0 (0.0) | 26 (14.8) | ||
| Bimatoprost | 17 (4.5) | 7 (6.5) | 10 (6.8) | 0 (0) | 116 (19.3) | 32 (14.8) | 22 (10.5) | 0 (0) | ||
| Alpha agonist: brimonidine | 73 (19.1) | 15 (14) | 29 (19.6) | 29 (22.8) | 0.228 | 92 (15.3) | 31 (14.4) | 31 (14.8) | 30 (17.1) | 0.741 |
| Combination of alpha agonist and beta blockers: brimonidine and timolol | 54 (14.1) | 11 (10.3) | 25 (16.9) | 18 (14.2) | 0.327 | 32 (5.3) | 8 (3.7) | 12 (5.7) | 12 (6.8) | 0.372 |
| Combination of CAIs and beta blockers: dorzolamide and timolol | 34 (8.9) | 10 (9.4) | 8 (5.4) | 16 (12.6) | 0.111 | 42 (7.0) | 13 (6) | 16 (7.7) | 13 (7.4) | 0.779 |
| CAIs | 41 (10.7) | 12 (11.2) | 20 (13.5) | 9 (7.1) | 0.225 | 17 (2.8) | 5 (2.3) | 4 (1.9) | 8 (4.6) | 0.255 |
| Brinzolamide | 30 (7.9) | 6 (5.6) | 16 (10.8) | 8 (6.3) | 13 (2.2) | 3 (1.4) | 3 (1.4) | 7 (4.0) | ||
| Dorzolamide | 11 (2.9) | 6 (5.6) | 4 (2.7) | 1 (0.8) | 4 (0.7) | 2 (0.9) | 1 (0.5) | 1 (0.6) | ||
| Others | 22 (5.8) | 6 (5.6) | 8 (5.4) | 8 (6.3) | 0.948 | 24 (4.0) | 5 (2.3) | 12 (5.7) | 7 (4.0) | 0.197 |
aChi-square test; significant at P < 0.05 (in bold).
bThe glaucoma treatment guideline does not recommend multiple PGAs in a therapy. Patients might refill second PGAs before running out of index PGA, and they no longer administer index PGAs.
CAI = carbonic anhydrase inhibitor; PGA = prostaglandin analog.