TABLE 7.

Results of TNF-IR Combination Therapy

	1 Year		2 Years
	Tofa + MTX	ADA + MTX	Tofa + MTX	ADA + MTX
Total cost	$25,227,134	$30,319,508	$53,022,456	$61,633,990
Cost PMPM	$2.10	$2.53	$2.21	$2.57
ACR20 responders	363	352	400	392
Cost per ACR20 responder	$69,575	$86,164	$132,500	$157,273

Note: For TNF-IR results, all therapies were administered as combination therapy with MTX. The analysis is based on 528 treated patients. The cost PMPM is based on the total number of 1 million organization (plan) members.

ACR = American College of Rheumatology; ADA = adalimumab; MTX = methotrexate; PMPM = per member per month; TNF-IR = tumor necrosis factor inhibitor inadequate responder; Tofa = tofacitinib.