TABLE 2.
Characteristics of Patients in the Commercial Groupa
| Overall (N = 54,145) | With Subsequent Fracture (n = 6,256) | Without Subsequent Fracture (n = 47,889) | P Value | |
|---|---|---|---|---|
| Index age (mean, SD) | 61.8 (8.9) | 64.1 (10.3) | 61.5 (8.6) | < 0.001 |
| Age groups, years | < 0.001 | |||
| 50-59 | 26,968 (49.8) | 2,653 (42.4) | 24,315 (50.8) | |
| 60-64 | 14,077 (26.0) | 1,495 (23.9) | 12,582 (26.3) | |
| 65-69 | 4,258 (7.9) | 523 (8.4) | 3,735 (7.8) | |
| 70-79 | 4,212 (7.8) | 636 (10.2) | 3,576 (7.5) | |
| 80-89 | 4,630 (8.6) | 949 (15.2) | 3,681 (7.7) | |
| ≥ 90 | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| Sex | < 0.001 | |||
| Male | 20,496 (37.9) | 2,040 (32.6) | 18,456 (38.5) | |
| Female | 33,647 (62.1) | 4,216 (67.4) | 29,431 (61.5) | |
| Geographic region | < 0.001 | |||
| Midwest | 17,436 (32.2) | 1,783 (28.5) | 15,653 (32.7) | |
| Northeast | 4,928 (9.1) | 618 (9.9) | 4,310 (9.0) | |
| South | 22,615 (41.8) | 2,696 (43.2) | 19,919 (41.6) | |
| West | 9,111 (16.8) | 1,150 (18.4) | 7,961 (16.6) | |
| Osteoporosis diagnosis | 3,412 (6.3) | 594 (9.5) | 2,818 (5.9) | < 0.001 |
| Pre-index medication use | ||||
| Osteoporosis medications | 4,581 (8.5) | 749 (12.0) | 3,832 (8.0) | < 0.001 |
| Fracture-related medications | 10,709 (19.8) | 1,365 (21.8) | 9,344 (19.5) | < 0.001 |
| Gastroprotective agents | ||||
| PPI | 7,875 (14.5) | 1,065 (17.0) | 6,810 (14.2) | < 0.001 |
| H2 receptor antagonist | 360 (0.7) | 54 (0.9) | 306 (0.6) | 0.122 |
| Cytoprotectant | 566 (1.1) | 86 (1.4) | 480 (1.0) | 0.025 |
| NSAIDs | 12,531 (23.1) | 1,601 (25.6) | 10,930 (22.8) | <0.001 |
| Glucocorticoids | 9,602 (17.7) | 1,284 (20.5) | 8,318 (17.4) | <0.001 |
| Estrogens | 2,569 (4.7) | 313 (5.0) | 2,256 (4.7) | 0.593 |
| Gastrointestinal events | 13,238 (24.5) | 1,768 (28.3) | 11,470 (24.0) | <0.001 |
| History of falls | 2,402 (4.4) | 344 (5.5) | 2,058 (4.3) | <0.001 |
| Charlson Comorbidity Index (mean, SD) | 0.71 (1.26) | 0.96 (1.50) | 0.67 (1.2) | <0.001 |
| Common osteoporosis-related comorbiditiesb | ||||
| Hypertension | 24,592 (45.4) | 3,221 (51.5) | 21,371 (44.6) | <0.001 |
| Arthritis | 20,026 (37.0) | 2,669 (42.7) | 17,357 (36.2) | <0.001 |
| Musculoskeletal pain | 15,434 (28.5) | 2,147 (34.3) | 13,287 (27.8) | <0.001 |
| Respiratory diseases | 12,505 (23.1) | 1,632 (26.1) | 10,873 (22.7) | <0.001 |
| Alzheimer’s disease, dementia, depression, anxiety, sleep disorders | 11,139 (20.6) | 1,601 (25.6) | 9,538 (19.9) | <0.001 |
aValues are presented as n (%) unless indicated otherwise.
bOnly comorbidities present in > 20% of patients are listed.
NSAID = nonsteroidal anti-inflammatory drug; PPI = proton pump inhibitor; SD = standard deviation.