TABLE 1.
Monkeya | % p11C, C-Mb-specific lysisc
|
|||
---|---|---|---|---|
PBL
|
Lymph node
|
|||
ConA–IL-2 expanded (50/25/13)d | p11C, C-M expanded (5/3/1) | ConA–IL-2 expanded (50/25/13) | p11C, C-M expanded (5/3/1) | |
GL9 | 13/07/04 | 40/35/30 | 57/52/39 | 27/21/15 |
3K1 | 25/16/08 | 45/34/28 | 07/04/02 | 12/07/05 |
403 | 43/40/32 | 60/60/56 | 41/34/29 | NTe |
138 | 18/13/06 | 68/66/58 | 50/46/40 | 38/34/26 |
575 | 11/07/05 | 14/09/05 | 08/04/01 | 16/10/06 |
154 | 39/27/14 | 60/58/48 | 15/08/04 | NT |
Chronically SIVmac-infected, Mamu-A*01+ rhesus monkeys.
p11C, C-M represents the optimal 9-amino-acid fragment of the SIV Gag 12-amino-acid peptide p11C.
Percent p11C, C-M-specific lysis was calculated as percent specific release by p11C, C-M-pulsed MHC class I-matched target cells minus the average of the percent release by control peptide p11B-pulsed target cells. The background level of p11B peptide-specific lysis was always less than 5% of the spontaneous release.
E/T ratio.
NT, not tested.