TABLE 5.
Phenotypic characterization of tetrameric Mamu-A*01/p11C, C-M-binding CD8αβ+ T cells of SIVmac-infected, Mamu-A*01+ rhesus monkeys
| Cell class subset | % Cells staining in SIV-infected, Mamu-A*01+ monkeya:
|
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GL9
|
3KI
|
403
|
138
|
575
|
154
|
Median
|
||||||||
| PBL | LN | PBL | LN | PBL | LN | PBL | LN | PBL | LN | PBL | LN | PBL | LN | |
| CD11a+ | 100 | 97.8 | 100 | 100 | 98.7 | 97.7 | 100 | 100 | 98.9 | 98.1 | 96.0 | 97.4 | 99.5 | 98.0 |
| CD28+ | 54.5 | 89.1 | 4.8 | 60.0 | 24.4 | 93.0 | 52.0 | 86.3 | 1.1 | 17.3 | 5.1 | 63.6 | 14.8 | 75.0 |
| CD45RA+ | 9.1 | 17.4 | 3.2 | 20.0 | 12.8 | 23.3 | 12.0 | 3.2 | 39.3 | 13.5 | 5.1 | 27.3 | 10.6 | 18.7 |
| CD49d+ | 100 | 97.8 | 98.4 | 97.5 | 99.4 | 97.7 | 100 | 97.1 | 98.9 | 94.2 | 98.0 | 100 | 99.2 | 97.6 |
| CD62L+ | 0 | 23.9 | 0 | 20.0 | 3.8 | 30.2 | 12.0 | 2.9 | 1.1 | 11.5 | 2.0 | 10.4 | 1.6 | 15.8 |
| CD95+ | 100 | 93.5 | 98.4 | 100 | 97.4 | 97.7 | 98.0 | 97.8 | 91.0 | 98.1 | 98.0 | 97.4 | 98.0 | 97.8 |
| MHC class II-DR+ | 63.6 | 28.3 | 90.5 | 97.5 | 26.9 | 60.5 | 34.0 | 86.7 | 36.0 | 92.3 | 83.8 | 96.1 | 49.8 | 89.5 |
a
Values represent the percentages of the Mamu-A*01/p11C, C-M complex population staining for expression of CD11a, CD28, CD45RA, CD49d, CD62L, CD95, and MHC class II-DR in PBL and in lymph node (LN) cells gated on CD8αβ+ T cells.