TABLE 2.

Most Common Depression Therapies Among the Matched TRD and Non-TRD Cohorts, Stratified by Line of Therapy

	TRD			Non-TRD
	First Line	Second Line	Third Line	First Line	Second Line
Most common therapies, by drug class, n (%)
SSRI	656 (82.0)	495 (61.9)	449 (56.1)	623 (77.9)	526 (65.8)
SNRI	41 (5.1)	175 (21.9)	251 (31.4)	54 (6.8)	155 (19.4)
Dopamine reuptake blocker	88 (11.0)	231 (28.9)	289 (36.1)	101 (12.6)	265 (33.1)
Tetracyclic	10 (1.2)	21 (2.6)	42 (5.3)	16 (2.0)	19 (2.4)
Antipsychotic	0 (0.0)	55 (6.9)	112 (14.0)	0 (0.0)	27 (3.4)
Other	6 (0.7)	35 (4.4)	57 (7.1)	6 (0.8)	27 (3.4)
Top 10 most common therapies, by drug, n (%)
Citalopram (SSRI)	187 (23.4)	65 (8.1)	35 (4.4)	196 (24.5)	67 (8.4)
Sertraline (SSRI)	169 (21.1)	78 (9.8)	38 (4.8)	162 (20.3)	95 (11.9)
Escitalopram (SSRI)	148 (18.5)	75 (9.4)	54 (6.8)	144 (18.0)	68 (8.5)
Fluoxetine (SSRI)	119 (14.9)	56 (7.0)	45 (5.6)	90 (11.3)	67 (8.4)
Bupropion (dopamine reuptake blocker)	88 (11.0)	98 (12.3)	67 (8.4)	101 (12.6)	102 (12.8)
Paroxetine (SSRI)	30 (3.8)			31 (3.9)
Venlafaxine (SNRI)	21 (2.6)	76 (9.5)	55 (6.9)	26 (3.3)	62 (7.8)
Duloxetine (SNRI)	13 (1.6)	49 (6.1)	41 (5.1)	18 (2.3)	43 (5.4)
Mirtazapine (tetracyclic)	10 (1.3)			16 (2.0)
Desvenlafaxine (SNRI)	7 (0.9)			10 (1.3)
Bupropion + sertraline (dopamine reuptake blocker + SSRI)		36 (4.5)	27 (3.4)		36 (4.5)
Bupropion + citalopram (dopamine reuptake blocker + SSRI)		27 (3.4)			35 (4.4)
Bupropion + escitalopram (dopamine reuptake blocker + SSRI)		26 (3.3)	28 (3.5)		38 (4.8)
Bupropion + fluoxetine (dopamine reuptake blocker + SSRI)			29 (3.6)

Note: Percentages do not sum to 100%.

SNRI = serotonin norepinephrine reuptake inhibitor; SSRI = selective serotonin reuptake inhibitor; TRD = treatment-resistant depression.