TABLE 3.
Annual All-Cause and Depression-Related HCRU During the 12-Month Follow-up Period Among Matched Cohorts
| Resource | TRD (n = 800) | Non-TRD (n = 800) | P Value | ||||
|---|---|---|---|---|---|---|---|
| Mean | SD | Median | Mean | SD | Median | ||
| All-cause resource utilization | |||||||
| Hospitalizations | 0.08 | 0.37 | 0.00 | 0.09 | 0.35 | 0.00 | 0.418 |
| ED visits | 0.29 | 0.86 | 0.00 | 0.24 | 0.82 | 0.00 | 0.047 |
| Outpatient visits | 17.96 | 16.95 | 13.00 | 13.39 | 13.93 | 8.50 | <0.001 |
| Other visitsa | 1.72 | 6.89 | 0.00 | 1.90 | 10.82 | 0.00 | 0.072 |
| Prescriptions | 29.86 | 25.03 | 23.00 | 23.99 | 22.25 | 18.00 | <0.001 |
| Depression-related resource utilization | |||||||
| Hospitalizations | 0.04 | 0.21 | 0.00 | 0.02 | 0.18 | 0.00 | 0.031 |
| ED visits | 0.04 | 0.21 | 0.00 | 0.02 | 0.15 | 0.00 | 0.013 |
| Outpatient visits | 6.47 | 10.89 | 3.00 | 3.24 | 7.27 | 1.00 | <0.001 |
| Other visitsa | 0.18 | 2.23 | 0.00 | 0.07 | 0.66 | 0.00 | 0.409 |
| Prescriptions | 10.12 | 7.02 | 9.00 | 6.54 | 5.92 | 5.00 | <0.001 |
Notes: The follow-up period was defined as (a) the 12-month period following the TRD index date for the TRD cohort, and (b) the 12-month period following a simulated index date for the non-TRD cohort. All-cause and depression-related HCRU were compared using nonparametric Wilcoxon signed-rank tests. A P value of < 0.05 was considered a statistically significant difference.
aOther includes home health care, hospice facility, inpatient rehab, outpatient psych, other location, other outpatient, skilled nursing facility, and surgical center.
ED = emergency department; HCRU=health care resource utilization; SD = standard deviation; TRD = treatment-resistant depression.