TABLE 2.
Baseline Clinical Characteristics and Treatment in the 60-Day Pre-Index Period for Patients in the All Patients Cohort and by Index LDL-C Level
| Index LDL-C | Alla | < 70 mg/dL | 70-99 mg/dL | 100-129 mg/dL | ≥ 130 mg/dL |
|---|---|---|---|---|---|
| Number of patients | 125,330 | 35,947 | 49,466 | 25,004 | 14,730 |
| LDL-C, mean (SD) | 90.72 (34.0) | 58.87 (17.5) | 85.93 (13.8) | 111.13 (15.1) | 149.82 (35.4) |
| CCI, mean (SD) | 1.99 (1.9) | 2.19 (2.0) | 1.95 (1.9) | 1.86 (1.9) | 1.82 (1.8) |
| Diabetes, % | 59.0 | 66.7 | 57.8 | 54.0 | 52.3 |
| Clinical ASCVD, % | |||||
| ACS | 8.6 | 9.8 | 8.4 | 7.0 | 7.6 |
| History of MI | 26.9 | 31.6 | 27 | 23.2 | 21.1 |
| Angina | 15.9 | 16.4 | 15.8 | 15.5 | 15.1 |
| PAD | 53.0 | 53.5 | 53.3 | 53.0 | 50.5 |
| IS | 9.6 | 10.3 | 9.3 | 9.4 | 9.4 |
| IS/TIA | 10.8 | 11.0 | 10.6 | 10.9 | 10.9 |
| TIA | 8.6 | 8.2 | 8.5 | 8.9 | 9.0 |
| Pre-index (60 days) statin intensity, % | |||||
| Low/medium | 35.0 | 31.6 | 38.3 | 39.1 | 25.8 |
| High | 35.5 | 45.3 | 36.5 | 27.5 | 22.2 |
| Combination | 0.3 | 0.4 | 0.3 | 0.2 | 0.2 |
Data source: Inovalon MORE2 Registry.
aThis category may include patients whose values are non-numerical and therefore not contained in the stratified LDL-C categories. Excluding patients whose values are non-numerical results in N = 125,147 (this population is also used in the therapy modification analysis).
ACS = acute coronary syndrome; ASCVD = atherosclerotic cardiovascular disease; CCI = Charlson Comorbidity Index; IS = ischemic stroke; LDL-C = low-density lipoprotein cholesterol; MI = myocardial infarction; PAD = peripheral artery disease; SD = standard deviation; TIA = transient ischemic attack.