TABLE 5.

Performance Metrics for All MTM Eligibility Criteria Tested in Overall Study Population Using 2 DTPs as the Gold Standard (N = 2,578,336)

Criteria Combination	Disease Count	Drug Count	Annual Drug Spend ($)	% of Study Cohort	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
2013 MTM criteria	≥ 3	≥ 8	≥ 3,144	7.0	15.3	95.6	51.3	78.8
1	≥ 1	≥ 3	≥ 150	64.9	88.6	42.3	31.8	92.5
2	≥ 1	≥ 6	≥ 150	51.5	79.3	56.9	35.9	90.0
3	≥ 1	≥ 10	≥ 150	28.4	53.5	79.2	43.8	84.9
4	≥ 2	≥ 3	≥ 150	47.2	75.0	61.2	37.0	88.9
5	≥ 2	≥ 6	≥ 150	39.5	67.8	69.1	40.0	87.6
6	≥ 2	≥ 10	≥ 150	23.0	46.6	84.1	47.2	83.8
7	≥ 3	≥ 3	≥ 150	20.6	40.2	85.4	45.5	82.5
8	≥ 3	≥ 6	≥ 150	18.6	37.5	87.1	47.0	82.1
9	≥ 3	≥ 10	≥ 150	12.3	27.7	92.3	52.3	80.8
10	≥ 1	≥ 3	≥ 656	45.2	69.7	62.3	36.0	87.1
11	≥ 1	≥ 6	≥ 656	40.2	65.8	67.6	38.2	86.7
12	≥ 1	≥ 10	≥ 656	25.8	49.2	81.3	44.5	84.1
13	≥ 2	≥ 3	≥ 656	34.6	59.8	73.1	40.3	85.7
14	≥ 2	≥ 6	≥ 656	31.6	56.8	76.0	41.9	85.3
15	≥ 2	≥ 10	≥ 656	21.1	43.1	85.6	47.6	83.2
16	≥ 3	≥ 3	≥ 656	16.8	33.9	88.5	47.2	81.5
17	≥ 3	≥ 6	≥ 656	15.9	32.7	89.2	47.9	81.4
18	≥ 3	≥ 10	≥ 656	11.6	26.0	92.8	52.3	80.5
19	≥ 1	≥ 3	≥ 2,239	23.1	39.7	82.0	40.1	81.7
20	≥ 1	≥ 6	≥ 2,239	21.5	38.4	83.6	41.6	81.7
21	≥ 1	≥ 10	≥ 2,239	15.8	31.6	89.0	46.5	81.1
22	≥ 2	≥ 3	≥ 2,239	18.4	34.6	86.5	43.8	81.3
23	≥ 2	≥ 6	≥ 2,239	17.5	33.6	87.5	44.9	81.3
24	≥ 2	≥ 10	≥ 2,239	13.2	28.0	91.3	49.3	80.7
25	≥ 3	≥ 3	≥ 2,239	10.1	21.2	93.3	49.1	79.6
26	≥ 3	≥ 6	≥ 2,239	9.8	20.8	93.6	49.6	79.5
27	≥ 3	≥ 10	≥ 2,239	7.8	17.8	95.2	53.1	79.2

DTPs = drug therapy problems; MTM = medication therapy management; NPV = negative predictive value; PPV = positive predictive value.