Criteria	Variable	Definition (ICD-9-CM or CPT Code)
Exclusion criteria	AF ablation	37.34, 37.33, 93650, 93651, 93652
	Cardioversion procedure valvular repair or replacement	92960, 92961, 99.61, 33405, 33420, 33422, 33425, 33426, 33427, 33430, 33496, 35.01-35.02, 35.11-35.12, 35.21-35.24, V42.2, V43.3
	Valvular diseases	394.xx, 396.xx, 746.5
	Hyperthyroidism	242.9
	Evidence of pregnancy	V22.x, pregnancy EMR table
Outcome	Stroke or systemic embolism	All stroke or systemic embolism
	Ischemic stroke	Primary hospital discharge record: 433.x1, 434.x1, 436
	Hemorrhagic stroke	Primary hospital discharge record: 430, 431
	Systemic embolism	Primary hospital discharge record: 444.0, 444.1, 444.2x, 444.8x, 444.9, 557.x, 593.81
	Major bleed	A bleeding event will be defined as major if it was an intracranial bleed or any other bleed that was associated with the following: inpatient care (primary and secondary diagnosis of major bleed), blood transfusion of 2 or more units of whole blood or red blood cells, decreased hemoglobin or hematocrit of 2 g/dL or more, physician guided medical or surgical treatment, or death.
	ICH	Primary or secondary hospital discharge record: 432.x Exclude ICH associated with a concomitant discharge diagnosis of major trauma (852.1, 852.3, 852.5, and 853.1)
	GI bleeding	Primary or secondary hospital discharge record: 530.21, 530.7, 530.82, 531.0x, 531.2x, 531.4x, 531.6x, 532.0x, 532.2x, 532.31, 532.4x, 532.6x, 534.0x, 534.2x, 534.4x, 534.6x, 535.x1, 537.83, 537.84, 537.89, 562.02, 562.03, 562.12, 562.13, 568.81, 569.3, 569.69, 569.85, 577.8, 578.x, 580.9, 596.7, 596.8, 599.7x
	Other bleeding (e.g., intraspinal, pericardial, intra-articular, and intramuscular)	Primary or secondary hospital discharge record: 255.41, 423.0, 455.2, 455.5, 455.8, 456.0, 456.2. 456.8, 459.0, 719.1x, 784.7, 784.8, 785.59, 786.3, 853.0x
	Others	To define major bleeding
	Physician-guided medical or surgical treatment	From primary or secondary hospital discharge record: 10140, 10160, 11740, 21501, 21502, 23030, 23930, 25028, 26990, 27301, 27603, 30000, 30020, 30901, 30903, 30905, 30906, 31238, 32110, 32654, 32658, 33020, 40800, 40801, 41000, 41005, 41006, 41007, 41008, 41009, 41015, 41016, 41017, 41018, 41800, 42960, 42961, 42962, 42970, 42971, 42972, 43227, 43255, 43460, 43501, 44366, 44378, 44391, 45317, 45334, 45382, 46614, 47350, 47360, 47361, 47362, 52606, 54700, 57023, 57180, 61108, 61154, 61156, 61312, 61313, 61314, 61315, 61322, 61323, 65930, 69000, 69005, 91100 ICD procedure codes: 44.43, 44.44, 44.49
Covariates	Congestive heart failure	428.x, 429.x
	Hypertension	401.x, 402.x, 403.x, 404.x, 405.x
	Diabetes mellitus	250.x
	Stroke or transient ischemic attack	433.x1, 434.x1, 435.x, 436 (in hospital or emergency room visit records)
	Peripheral vascular disease	443.x
	Liver cirrhosis	571.2, 571.5, or 571.6
	Cardiomyopathy	425.x
	Dementia	290.xx, 294.1x
	Bleed	530.21, 530.7, 530.82, 531.0x, 531.2x, 531.4x, 531.6x, 532.0x, 532.2x, 532.31, 532.4x 532.6x, 534.0x, 534.2x, 534.4x, 534.6x, 535.x1, 537.83, 537.84, 537.89, 562.02, 562.03, 562.12, 562.13, 568.81, 569.3, 569.69, 569.85, 577.8, 578.x, 580.9, 596.7, 596.8, 599.7x, 255.41, 423.0, 455.2, 455.5, 455.8, 456.0, 456.2. 456.8, 459.0, 719.1x, 784.7, 784.8, 785.59, 786.3, 853.0x
	Myocardial infarction	410.x (primary hospital discharge)
	Mechanical fall	E880–E888 (in hospital or emergency room visit records)
	Asthma/COPD/pulmonary embolism	493.x, 491.x, 492.x, 496.x, 415.1x, 416.2
	Drug/alcohol dependence	303.x, 304.x
	Malignancy	140.0-149.9, 150.0-159.9, 160.0-165.9, 170.0-170.9, 171.0-171.9, 172.0-172.9, 173.0-173.9, 174.0-175.9, 176.0-176.9, 179, 180.0-180.9, 181, 182.0-183.9, 184.0-184.9, 186.0-187.9, 188.0-188.9, 189.0-189.9, 190.1-190.9, 191.0-191.9, 192.0-192.9, 193, 194.0-194.9, 195.0-195.8, 196.0-198.89, 199.0-1S99.2, 200.00-202.98, 203.00-203.02, 203.10-203.12, 209.0-209.3, 235.0-235.9, 236.0-236.4, 236.6-236.91, 237.0-238.3
Medication	Warfarin	GPI code: 77204030002010, 77204030002005, 77204030000305
	Periprocedural anticoagulation (heparin, bivalrudin, and low-molecular-weight heparin)	GPI class code: 8310
	Antiarrythmic medications (quinidine, procainamide, disopyramide, propafenone, flecainide, amiodaron, dofetilide, and ibutilide, dronedarone)	GPI class code: 3510, 3520, 3530, 3540
	Clopidogrel, ticlopidine, and prasugrel, ticagrelor	GPI code: 85158020100320, 85158080100320
	Heart rate control medications: beta-blocker, calcium channel blocker, Digoxin	GPI class code: 3120, 3310, 3320, 3330, 34
	Secondary prevention medications (statins, angiotensin-converting engyme inhibitors, and angiotensin receptor blockers)	GPI class code: 3610, 3610, 3615, 3699, 3940

AF = atrial fibrillation; COPD = chronic obstructive pulmonary disease; CPT = Current Procedural Terminology; GI = gastrointestinal; GPI = Generic Product Identifier; ICD-9-CM = International Classification of Diseases, Ninth Revision, Clinical Modification; ICH = intracerebral hemorrhage.