TABLE 4.

Stroke or Systemic Embolism Outcomes by Pharmacist Interventions and TTRs

	Patients, n	Stroke or Systemic Embolism, n	Stroke or Systemic Embolism Rate, 100 Person-Years	Adjusted HR (95% CI)a
TTR < 65% and frequent managementb	10,837	452	1.88	1.94 (1.66-2.27)
TTR < 65% and less frequent management	8,204	385	1.54	1.91 (1.63-2.23)
TTR ≥ 65% and frequent management	4,853	132	1.02	1.10 (0.89-1.36)
TTR ≥ 65% and less frequent management	8,180	270	0.82	Reference
Total	32,704	1,239	1.30

^aAdjusted for age; sex; race/ethnicity; baseline conditions (stroke/trasient ischemic attack and dementia); baseline number of emergency visits/hospitalizations; baseline medication use (anti-arrythmic medication, heart rate control, and periprocedural anticoagulation); and CHADS₂ scores.

^bFrequent management was defined by number of pharmacist interventions (pharmacists contact with patients, mostly through telephone counseling) >16 times per year (above median).

CI = confidence interval; HR = hazard ratio; TTR = time-in-therapeutic range.