TABLE 1.
Patient Characteristics at Baseline
| All (N = 4,071) | Radiotherapy (n = 995) | Temozolomide (n = 103) | Temozolomide + Radiotherapy (n = 2,973) | |
|---|---|---|---|---|
| Age, mean (SD), years | 54.9 (13.3) | 57.1 (16.6) | 47.8 (14.4) | 54.4 (11.8) |
| Age group, years, n (%) | ||||
| 18-34 | 350 (8.6) | 118 (11.9) | 20 (19.4) | 212 (7.1) |
| 35-64 | 2,925 (71.8) | 489 (49.1) | 73 (70.9) | 2,363 (79.5) |
| 65-74 | 535 (13.1) | 232 (23.3) | 7 (6.8) | 296 (10.0) |
| ≥ 75 | 261 (6.4) | 156 (15.7) | 3 (2.9) | 102 (3.4) |
| Women, n (%) | 1,693 (41.6) | 445 (44.7) | 39 (37.9) | 1,209 (40.7) |
| Region, n (%) | ||||
| Northeast | 742 (18.2) | 200 (20.1) | 18 (17.5) | 524 (17.6) |
| North Central | 1,091 (26.8) | 274 (27.5) | 26 (25.2) | 791 (26.6) |
| South | 1,489 (36.6) | 362 (36.4) | 35 (34.0) | 1,092 (36.7) |
| West | 683 (16.8) | 146 (14.7) | 20 (19.4) | 517 (17.4) |
| Unknown | 66 (1.6) | 13 (1.3) | 4 (3.9) | 49 (1.6) |
| Patient residence, n (%) | ||||
| Urban | 3,385 (83.1) | 802 (80.6) | 88 (85.4) | 2,495 (83.9) |
| Rural | 623 (15.3) | 181 (18.2) | 12 (11.7) | 430 (14.5) |
| Unknown | 63 (1.5) | 12 (1.2) | 3 (2.9) | 48 (1.6) |
| Medicare beneficiary, n (%) | 746 (18.3) | – | – | – |
| Plan type, n (%) | ||||
| Health maintenance organization | 393 (9.7) | 71 (7.1) | 16 (15.5) | 306 (10.3) |
| Preferred provider organization | 2,439 (59.9) | 564 (56.7) | 50 (48.5) | 1,825 (61.4) |
| Other | 1,117 (27.4) | 322 (32.4) | 31 (30.1) | 764 (25.7) |
| Missing | 122 (3.0) | 38 (3.8) | 6 (5.8) | 78 (2.6) |
| Employment status, n (%) | ||||
| Active full time | 1,620 (39.8) | 275 (27.6) | 50 (48.5) | 1,295 (43.6) |
| Active part time/seasonal | 32 (0.8) | 6 (0.6) | 2 (1.9) | 24 (0.8) |
| Retiree | 881 (21.6) | 344 (34.6) | 10 (9.7) | 527 (17.7) |
| Other/unknown | 1,538 (37.8) | 370 (37.2) | 41 (39.8) | 1,127 (37.9) |
| CCI score, mean (SD) | 0.8 (1.2) | 0.9 (1.3) | 0.5 (1.1) | 0.8 (1.2) |
| CCI score, n (%) | ||||
| 0 | 2,071 (50.9) | 458 (46.0) | 67 (65.0) | 1,546 (52.0) |
| 1-2 | 1,763 (43.3) | 457 (45.9) | 32 (31.1) | 1,274 (42.9) |
| 3-4 | 134 (3.3) | 55 (5.5) | 2 (1.9) | 77 (2.6) |
| ≥ 5 | 103 (2.5) | 25 (2.5) | 2 (1.9) | 76 (2.6) |
| CCI component, n (%) | ||||
| Cerebrovascular disease | 1,360 (33.4) | 347 (34.9) | 21 (20.4) | 992 (33.4) |
| Diabetes | 536 (13.2) | 175 (17.6) | 7 (6.8) | 354 (11.9) |
| Chronic pulmonary disease | 329 (8.1) | 101 (10.2) | 4 (3.9) | 224 (7.5) |
| Hemiplegia or paraplegia | 313 (7.7) | 81 (8.1) | 7 (6.8) | 225 (7.6) |
| Congestive heart failure | 121 (3.0) | 45 (4.5) | 4 (3.9) | 72 (2.4) |
| Metastatic solid tumor | 80 (2.0) | 18 (1.8) | 2 (1.9) | 60 (2.0) |
| Renal disease | 76 (1.9) | 24 (2.4) | 1 (1.0) | 51 (1.7) |
| Peripheral vascular disease | 68 (1.7) | 29 (2.9) | 1 (1.0) | 38 (1.3) |
| Myocardial infarction | 56 (1.4) | 20 (2.0) | 1 (1.0) | 35 (1.2) |
| Liver disease | 30 (0.7) | 9 (0.9) | 2 (1.9) | 19 (0.6) |
| Rheumatic disease | 27 (0.7) | 10 (1.0) | 1 (1.0) | 16 (0.5) |
| Dementia | 19 (0.5) | 6 (0.6) | 0 (0.0) | 13 (0.4) |
| Peptic ulcer disease | 12 (0.3) | 5 (0.5) | 0 (0.0) | 7 (0.2) |
| AIDS/HIV | 4 (0.1) | 0 (0.0) | 0 (0.0) | 4 (0.1) |
AIDS = acquired immune deficiency syndrome; CCI = Charlson Comorbidity Index; CVD = cardiovascular disease; HIV = human immunodeficiency virus; SD = standard deviation.