TABLE 4.
Drug Cost Thresholds
| Second Line, $ | Third Line, $ | |||||
|---|---|---|---|---|---|---|
| WTP Threshold | 50,000 | 100,000 | 150,000 | 50,000 | 100,000 | 150,000 |
| CFZ-LEN-DEX | 55 | 649 | 1,242 | 0 | 445 | 946 |
| (−906-1,063) | (−68-1,733) | (405-2,661) | (−938-622) | (−633-1,518) | (−386-2,417) | |
| ELO-LEN-DEX | −69 | 252 | 572 | −126 | 162 | 449 |
| (−535-619) | (−141-903) | (138-1,272) | (−644-484) | (−266-692) | (34-1,032) | |
| IX-LEN-DEX | −278 | 127 | 533 | -347 | 19 | 385 |
| (−903-567) | (−294-830) | (84-1,329) | (−1,046-593) | (−502-769) | (−40-1,180) | |
| PAN-BOR-DEX | 3,459 | 4,344 | 5,229 | |||
| (2,389-5,552) | (2,668-8,242) | (2,792-10,987) | ||||
| DAR-LEN-DEX | −165 | 567 | 1,298 | −293 | 351 | 995 |
| (−779-486) | (−51-1,239) | (614-2,093) | (−902-417) | (−239-1,080) | (338-1,800) | |
| DAR-BOR-DEX | 1,840 | 2,582 | 3,324 | 1,708 | 2,397 | 3,087 |
| (1,495-2,278) | (2,139-3,050) | (2,674-3,976) | (1,374-2,114) | (1,948-2,959) | (2,479-3,845) | |
Note: Results reflect threshold prices for the first listed drug in each triplet regimen only (all other parameter values held constant).
BOR = bortezomib; CFZ = carfilzomib; DAR = daratumumab; DEX = dexamethasone; ELO = elotuzumab; IX = ixazomib; LEN = lenalidomide; PAN = panobinostat; WTP = willingness to pay.