TABLE 7.
Pharmacokinetic parameters after administration of Icariin in C57 mice (Mean ± SD, n = 5).
| Parameters | Unit | Intravenous injection of 15 mg kg−1 ICA | Results of ICII after intragastric administration of ICA | ||||
|---|---|---|---|---|---|---|---|
| ICA | ICI | ICII | 30 mg kg−1 | 90 mg kg−1 | 150 mg kg−1 | ||
| T1/2 | h | 2.25 ± 2.00 | 0.47 ± 0.18 | 2.8 ± 0.84 | 1.65 ± 0.65 | 1.53 ± 0.44 | 2.49 ± 0.55 |
| Tmax | h | 0.03 ± 0.00 | 0.03 ± 0.00 | 0.03 ± 0.00 | 2.00 ± 0.00 | 2.00 ± 0.35 | 1.80 ± 0.45 |
| Cmax | ng·mL−1 | 13,266.22 ± 5,589.44 | 187.89 ± 39.17 | 32.13 ± 10.43 | 51.68 ± 15.01 | 146.87 ± 32.41 | 225.49 ± 20.29 |
| AUC (0-t) | h·ng·mL−1 | 1,299.44 ± 480.92 | 17.08 ± 3.49 | 8.46 ± 3.08 | 50.97 ± 19.30 | 161.16 ± 34.02 | 273.85 ± 27.82 |
| AUC (0-∞) | h·ng·mL−1 | 1,302.03 ± 484.95 | 17.46 ± 3.64 | 10.10 ± 2.910 | 53.80 ± 19.20 | 162.18 ± 33.95 | 278.19 ± 28.04 |
| V | L·kg−1 | 32.42 ± 19.68 | 574.66 ± 121.08 | 6,254.2 ± 1869.39 | 1,532.73 ± 869.85 | 1,346.58 ± 781.71 | 1980.14 ± 578.30 |
| CL | L·h−1·kg−1 | 12.65 ± 3.92 | 892.88 ± 205.69 | 1,592.58 ± 480.14 | 628.09 ± 258.15 | 578.57 ± 142.79 | 545.39 ± 59.36 |