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Fiber deletion in pDV44 and genomic structures of the Ad5.βgal.ΔF and Ad5.βgal.wt vectors. (A) pDV44 was constructed by removing the fiber gene and residual E3 sequences (nt 30819 to 32743 of Ad5) from pBHG10 (see Materials and Methods). ITRs, inverted terminal repeats. (B) Viruses constructed by cotransfection of either pBHG10 or pDV44 with pΔE1Bβgal. Both are E1/E3-lacking Ad5 vectors, and Ad5.βgal.ΔF has the additional fiber (L5) deletion as in pDV44.
