TABLE 6.

PK analysis of time profiles for CKD patients.

PK parameter	Data type	Healthy	CKD
			Mild	Moderate	Severe
AUC [μg/mL*h]	Predicted	1,037	1,454.63	2,011.93	2,211.58
	Observed	894.77	1,558.10	1,970.87	2,025.89
	Fold error	1.16	1.07	1.02	1.09
T½ [h]	Predicted	7.67	9.40	12.88	13.08
	Observed	8.96	14.69	15.30	15.42
	Fold error	1.17	1.56	1.19	1.18
Clearance [mL/min]	Predicted	16.10	11.45	8.30	7.54
	Observed	20.05 ± 3.15	11.75 ± 4.20	8.82 ± 1.62	10.05 ± 2.95
	Fold error	1.25	1.03	1.06	1.33