TABLE 7.

Ratio of trough concentrations at steady state to the trough concentrations after the first application, as estimation of accumulation index.

Regimen	Healthy		CKD
	Simulated	Observed	Simulated
0.5 g, q12h, for 4 days	1.50	1.33	2.20
1 g, q12h, for 4 days	1.50	1.20	2.30
2 g, q12h, for 4 days	1.50	1.31	2.23
2 g, q24h, for 4 days	1.24	1.20	1.50