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. 2023 Jun 29;24(8):e57550. doi: 10.15252/embr.202357550

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© 2023 The Authors. Published under the terms of the CC BY NC ND 4.0 license.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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This possible model proposes that MATR3 proteins and AS L1 RNAs phase‐separate into a dynamic meshwork, thereby facilitating the 3D organization of chromatin that transcribed AS L1 RNAs.