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The synthesis of BRD4 degraders using achiral CRBN ligands. Reagents and conditions: (a) TFA/DCM, rt; (b) JQ-1 (carboxylic acid), HATU, DIPEA, DMF, rt, (a) and (b) total yield 86%; (c) 4-(N-Boc-amino)piperidine (or 4-(Aminoethyl)-1-N-Boc-piperidine), HATU, DIPEA, DMF, rt, yield 80%.
