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. 2023 Jun 12;39(5):332–346. doi: 10.1089/jop.2022.0184

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Copyright 2023, Mary Ann Liebert, Inc., publishers

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FIG. 1. — Mean plasma concentration versus time profiles of QLS-101 and levcromakalim in Dutch belted rabbits. (A) Plasma concentrations of QLS-101 following once-daily topical ocular administration of 3 concentrations of QLS-101 for 28 consecutive days. (B) Plasma concentrations of levcromakalim following once-daily topical ocular administration of 3 concentrations of QLS-101 for 28 consecutive days. Presence of levcromakalim in plasma confirms conversion of QLS-101 to levcromakalim. Solid lines represent day 1 and dashed lines represent day 28 data.