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Cardiovascular outcomes in beagle dogs after intravenous administration of QLS-101. Effect of single intravenous doses of QLS-101 at doses of 0 (dark blue), 0.075 (red), 0.5 (green), and 1.5 mg/kg (light blue) on (A) body temperature, (B) systolic blood pressure, (C) diastolic blood pressure, (D) mean arterial pressure, (E) mean pulse pressure, and (F) mean heart rate. Data are expressed as the mean change from predose baseline ± standard error of mean.
