Table 2.

Ocular Tissue Pharmacokinetic Parameters for QLS-101 in Dutch Belted Rabbits Following Topical Ophthalmic Administration

		Day 6			Day 17		Day 28
Dose solution (mg/eye/dose)	Tissue	Cmax (ng/g)	AUC0–23h (h × ng/g)	Tmax (h)	Cmax (ng/g)	Tmax (h)	Cmax (ng/g)	AUC0–23h (h × ng/g)	Tmax (h)
0.16	Cornea	1,510	24,900	4	885	2	82	1,310	4
0.16	Aqueous Humor	BLQ	BLQ	BLQ	BLQ	BLQ	6.29	66.1	4
0.16	Conjunctiva	161	1,980	BLQ	116	2	640	8,920	23
0.16	Sclera	3,570	50,000	4	580	4	58.5	1,010	4
0.16	Lacrimal gland	128	2,790	23	126	4	79.3	958	4
0.16	Iris/CB	117	1,320	2	28.9	2	BLQ	BLQ	BLQ
0.16	Lens	5.91	11.8	2	BLQ	BLQ	BLQ	BLQ	BLQ
0.16	Vitreous	45.4	498	4	4.5	4	9.85	9.85	BLQ
0.16	Fat	46.1	596	4	41.4	2	81.9	1,510	4
0.16	Retina	448	5,410	4	75.7	4	BLQ	BLQ	BLQ
0.16	Optic nerve	255	3,650	4	48.3	4	BLQ	BLQ	BLQ
0.8	Cornea	6,680	104,000	4	2,440	4	416	4,330	2
0.8	Aqueous humor	142	1,770	4	32.9	2	29.4	315	2
0.8	Conjunctiva	1,590	14,300	2	506	BLQ	2,390	31,200	4
0.8	Sclera	3,330	37,600	2	857	4	237	3,850	4
0.8	Lacrimal gland	219	3,720	4	437	4	219	2,850	2
0.8	Iris/CB	581	3,920	2	142	4	23.1	199	2
0.8	Lens	101	248	2	BLQ	BLQ	BLQ	BLQ	BLQ
0.8	Vitreous	10.4	109	4	BLQ	BLQ	BLQ	BLQ	BLQ
0.8	Fat	168	1,200	2	90.5	2	259	2,630	2
0.8	Retina	104	2,090	23	96.8	2	28.8	254	2
0.8	Optic nerve	165	910	2	47.9	2	19.1	38.3	2

BLQ, below limit of quantification; CB, ciliary body.