Table 4.
Summary of Observed Eye Redness During Gross Ocular Examination in Dutch Belted Rabbits Dosed Once Daily by Topical Ophthalmic Administration with Various QLS-101 Concentrations for 28 Days
| Treatment | Eye | Day |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| −7 |
3 |
7 |
14 |
21 |
28 |
29 |
42 |
||
| Number of eyes (severity level)a | |||||||||
| Formulation buffer | OD | — | — | — | — | — | 1 (2) | — | — |
| OS | — | — | — | — | — | 1 (2) | — | — | |
| QLS-101 (0.8 mg/eye/dose) | OD | — | — | — | 1 (2) | — | 2 (2) | — | N/A |
| OS | — | — | — | — | — | 3 (2) | 1 (2) | N/A | |
| QLS-101 (1.6 mg/eye/dose) | OD | — | — | — | 1 (2) | — | 3 (2) | — | N/A |
| OS | — | — | — | 1 (1) | — | — | — | N/A | |
| QLS-101 (3.2 mg/eye/dose) | OD | — | 1 (2) | 1 (2) | 2 (2) | — | 3 (2) | — | — |
| OS | — | 1 (2) | — | — | — | 6 (2) | — | — | |
a
Values represent the number of animals identified with ocular redness. Number in parenthesis represents the magnitude of observed redness (1 = very mild; 2 = mild). No other relevant findings were observed during gross ocular examination.
N/A, not available; OD, right eye; OS, left eye.