Table 8.
Summary of Clinical Findings in Beagle Dogs Dosed Intravenously with QLS-101
| Finding | 0.05 mg/kg |
0.5 mg/kg |
1.5 mg/kg |
3 mg/kg |
5 mg/kg |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| M | F | M | F | M | F | M | F | M | F | |
| Pinna redness | X | — | X | — | X | X | X | X | X | X |
| Limb redness | — | — | — | X | — | X | X | X | — | — |
| Gingiva redness | — | — | — | — | — | X | X | X | X | X |
| Generalized redness | — | — | — | — | — | — | X | X | X | X |
| Abnormally increased heart rate | — | — | — | — | — | — | — | — | X | X |
| Warm to touch | — | — | — | — | — | — | — | — | X | X |
| Partly closed eyes | — | — | — | — | — | — | — | — | X | — |
X represents positive response. — Represents no observed indication.
F, female; M, male.